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Optical and Power Source Integrated Paper Microfluidic Devices for Point of Care Systems

Venkatraman, Vishak
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1505206620429159

Abstract Details

2017, PhD, University of Cincinnati, Engineering and Applied Science: Electrical Engineering.
The goal of this project is to a create point-of-care (POC) diagnostic device with several desirable characteristics, combining high sensitivity and semi-quantitative output in a cost effective and disposable package. Another important component of a POC system is power, and in this thesis, several options were explored. The biosensor used in this project is lateral flow immunoassay (LFIA), which is a paper based device. LFIAs have several desirable characteristics such as capillary action for fluid transport and affinity to proteins that makes them ideal candidates for Lab-on- Chip (LOC) applications. The POC described in this paper is a combination of LFIA and organic optoelectronics as the signal detection component. Organic light emitting diodes (OLEDs) and organic photodiodes (OPDs) have been found to be desirable candidates over their inorganic counterparts for POC applications. Organic devices provide the distinct advantages of having planar form factor and large active area in nature which is suitable for the integration with LFIAs. First, phosphorescence-based green OLEDs fabricated on plastic substrates were integrated as excitation light sources for fluorescent quantum dot (QD)-based LFIA devices. A 10× improvement in visual signal intensity was achieved compared to conventional LFIA, resulting in a 7× improvement in the limit-of-detection (LOD) of 3 nM concentration. For power source options, a zero-power (on board) system was designed on a flexible plastic substrate. The system utilized the power provided by near field communication (NFC) antenna to an LED array formed on the same substrate using hybrid manufacturing techniques. Such a system can harvest power from smartphones, which are a ubiquitous presence in this digital century. The NFC LED chip was used to excite the QD-based fluorescent LFA, which demonstrated again a ~10× higher sensitivity compared to conventional commercial devices. The hybrid manufacturing approach using roll-to-roll manufacturing and integration has the potential to significantly decrease the fabrication cost. Finally, the LFIA was integrated with organic optoelectronics devices on plastic as the detector component as a step toward a fully integrated lab-on-chip device. An organic photodiode (OPD) that absorbs at green wavelengths has been used. The quantitative measurements have utilized optical transmission mode through an LFIA strip that forms red colored lines by the accumulation of gold nanoparticles (AuNP). In this configuration, the amount of transmitted light decreases as the number of Au NPs accumulate on the test line, which directly correlates with the analyte concentration. This change in optical intensity results in a change as change in the OPD photocurrent. We have successfully created such a prototype and have done a quantitative measurement of the analyte.
Andrew Steckl, Ph.D. (Committee Chair)
Fred Beyette, Ph.D. (Committee Member)
Leyla Esfandiari, Ph.D. (Committee Member)
Kenneth James Kozak, B.A. (Committee Member)
Ian Papautsky, Ph.D. (Committee Member)
114 p.
Electrical Engineering
LFIA; QDot; OLED; OPD; Organic electronics; biosensors

Recommended Citations

Citations

  • Venkatraman, V. (2017). Optical and Power Source Integrated Paper Microfluidic Devices for Point of Care Systems [Doctoral dissertation, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1505206620429159

    APA Style (7th edition)

  • Venkatraman, Vishak. Optical and Power Source Integrated Paper Microfluidic Devices for Point of Care Systems. 2017. University of Cincinnati, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1505206620429159.

    MLA Style (8th edition)

  • Venkatraman, Vishak. "Optical and Power Source Integrated Paper Microfluidic Devices for Point of Care Systems." Doctoral dissertation, University of Cincinnati, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1505206620429159

    Chicago Manual of Style (17th edition)

ucin1505206620429159
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This open access ETD is published by University of Cincinnati and OhioLINK.