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BMP Signaling and Intersecting Molecular Mechanisms in Calcific Aortic Valve Disease

Gomez Stallons, Maria V
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1468335864

Abstract Details

2016, PhD, University of Cincinnati, Medicine: Molecular and Developmental Biology.
Calcific Aortic Valve Disease (CAVD) is the most prevalent type of heart valve disease, affecting ~2% of the US population. The risk for developing CAVD increases with age, and CAVD is becoming more common with increased average lifespan. Currently, the standard of care involves aortic valve (AoV) replacement surgery, which is often contraindicated for the elderly. Importantly, the pathogenic mechanisms driving CAVD, which could serve as potential therapeutic targets, are not well understood. Studies of human diseased AoV provide initial evidence that the Bone Morphogenetic Proteins (BMPs), essential for normal bone formation, play a critical role during CAVD. However, the function of BMP signaling during osteochondrogenic gene induction and AoV calcification, both CAVD features, remain unknown. Here, studies are directed towards the understanding of molecular pathways involved in CAVD using a combination of a murine model of premature aging in vivo and directed mechanistic studies of porcine aortic valve interstitial cells (VICs) in vitro.
Katherine Yutzey, Ph.D. (Committee Chair)
Burns Blaxall, Ph.D. (Committee Member)
Rolf Stottman, PhD (Committee Member)
James Wells, Ph.D. (Committee Member)
Yana Zavros, Ph.D. (Committee Member)
266 p.
Molecular Biology
Calcific Aortic Valve Disease; Bone Morphogenetic Proteins; Smads1 5 8; Klotho-deficient mice; Porcine aortic VICs

Recommended Citations

Citations

  • Gomez Stallons, M. V. (2016). BMP Signaling and Intersecting Molecular Mechanisms in Calcific Aortic Valve Disease [Doctoral dissertation, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1468335864

    APA Style (7th edition)

  • Gomez Stallons, Maria. BMP Signaling and Intersecting Molecular Mechanisms in Calcific Aortic Valve Disease. 2016. University of Cincinnati, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1468335864.

    MLA Style (8th edition)

  • Gomez Stallons, Maria. "BMP Signaling and Intersecting Molecular Mechanisms in Calcific Aortic Valve Disease." Doctoral dissertation, University of Cincinnati, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1468335864

    Chicago Manual of Style (17th edition)

ucin1468335864
333
© 2016, all rights reserved.
This open access ETD is published by University of Cincinnati and OhioLINK.