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12786.pdf (56.21 MB)
ETD Abstract Container
Abstract Header
The roles of Vegf and Stabilin-2 signaling during arterial-venous differentiation
Author Info
Rost, Megan S.
Permalink:
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1427883233
Abstract Details
Year and Degree
2015, PhD, University of Cincinnati, Medicine: Molecular and Developmental Biology.
Abstract
Proper blood vessel development is crucial not only in embryonic development, but also in maintaining proper organ functionality throughout adulthood. The heart and blood vessels transport oxygen, metabolites, waste products, and immune response signals to all tissues of the body. Without proper development of arteries and veins, these functions would not be possible. This dissertation focuses on understanding how these two major vessel types are developed. We investigate the roles of two proteins, Stabilin-2 (Stab2) and Ets Varient 2 (Etv2), and how they function in relation to Vascular endothelial growth factor (Vegf) signaling to regulate vascular endothelial cell differentiation and arterial venous specification.
Committee
Saulius Sumanas, Ph.D. (Committee Chair)
Richard Lang, Ph.D. (Committee Member)
Jerry Lingrel, Ph.D. (Committee Member)
Joshua Waxman, Ph.D. (Committee Member)
Katherine Yutzey, Ph.D. (Committee Member)
Pages
163 p.
Subject Headings
Developmental Biology
Keywords
Vascular
;
Etv2
;
Vegf
;
Stab2
;
Arterial
;
Venous
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Citations
Rost, M. S. (2015).
The roles of Vegf and Stabilin-2 signaling during arterial-venous differentiation
[Doctoral dissertation, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1427883233
APA Style (7th edition)
Rost, Megan.
The roles of Vegf and Stabilin-2 signaling during arterial-venous differentiation.
2015. University of Cincinnati, Doctoral dissertation.
OhioLINK Electronic Theses and Dissertations Center
, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1427883233.
MLA Style (8th edition)
Rost, Megan. "The roles of Vegf and Stabilin-2 signaling during arterial-venous differentiation." Doctoral dissertation, University of Cincinnati, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1427883233
Chicago Manual of Style (17th edition)
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Document number:
ucin1427883233
Download Count:
413
Copyright Info
© 2015, all rights reserved.
This open access ETD is published by University of Cincinnati and OhioLINK.