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Association of Allergic Diseases with Internalizing Disorders in Early Childhood

Nanda, Maya, M.D.
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1397735065

Abstract Details

2014, MS, University of Cincinnati, Medicine: Clinical and Translational Research.
Background: The association between allergic disease and behavioral symptoms in childhood is not well established. Objective: To longitudinally examine the relationship of allergic diseases and atopy at age four with validated measures of internalizing, anxiety, and depressive symptoms at age 7 years. Methods: Children enrolled in the Cincinnati Childhood Allergy and Air Pollution Study (CCAAPS), a birth cohort study, completed skin prick testing (SPT) and clinical examinations at 1, 2, 3, 4, and 7 years of age. At age seven, parents completed the Behavior Assessment System for Children, Second Edition (BASC-2), a validated psychological assessment of internalizing disorders composite scale including subscales anxiety and depression. The associations between rhinitis, persistent wheezing, eczema, and allergic sensitization at age four and internalizing disorders at age seven are examined by logistic and linear regression adjusting for maternal education, gender, parental asthma, BMI, and sleep disturbance. Results: In a cohort of 546 children with complete information on allergic disease and behavioral symptoms, the prevalence of internalizing disorders was 13.4%, anxiety disorders 15.2%, and depression was 10.8%. Allergic rhinitis at age 4 years was significantly associated with having elevated BASC-2 scores in the clinically `at risk’ range for internalizing disorders, (aOR=3.2 [1.8-5.8]), anxiety disorders (aOR=2.0 [1.2-3.6]), and depressive disorders (aOR=3.2 [1.7-6.5]). Atopic persistent wheeze at age 4 years was significantly associated with BASC-2 `at risk’ score for internalizing disorders (aOR=2.7 [1.2-6.3]). Aeroallergen sensitization and food sensitization alone were not associated with BASC-2 `at risk’ score for internalizing, anxiety, or depressive disorders. Presence of more than one allergic disease (rhinitis, persistent wheeze, or eczema) was significantly associated with BASC-2 `at risk’ score for internalizing disorders (aOR=4.0 [2.0-8.0]), anxiety disorders (aOR=2.5 [1.2-5.0]), and depressive disorders (aOR=3.5 [1.6-7.7]). Presence of rhinitis plus another allergic disease had an even stronger association than rhinitis alone with internalizing disorders (aOR=5.2 [2.6-10.8]), anxiety disorders (aOR=2.5 [1.2-5.4]), and depressive disorders (aOR=4.4 [1.9-10.0]). Multivariate linear regression showed same associations between allergic diseases and BASC-2 continuous outcome. Conclusions: Children with allergic diseases at age 4, in particular rhinitis, persistent wheeze, are more likely to be at-risk for internalizing disorders including anxiety and depression at 7 years. Furthermore, there was an additive risk of having more than one allergic disease on the subsequent development of an internalization disorder.
Erin Nicole Haynes, Ph.D. (Committee Chair)
Amal Halim Assa'ad, M.D. (Committee Member)
Linda Levin, Ph.D. (Committee Member)
Patrick Ryan, Ph.D. (Committee Member)
30 p.
Surgery
anxiety; depression; internalizing disorders; allergic rhinitis; multiple allergic diseases; wheezing

Recommended Citations

Citations

  • Nanda, M.D., M. (2014). Association of Allergic Diseases with Internalizing Disorders in Early Childhood [Master's thesis, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1397735065

    APA Style (7th edition)

  • Nanda, M.D., Maya. Association of Allergic Diseases with Internalizing Disorders in Early Childhood. 2014. University of Cincinnati, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1397735065.

    MLA Style (8th edition)

  • Nanda, M.D., Maya. "Association of Allergic Diseases with Internalizing Disorders in Early Childhood." Master's thesis, University of Cincinnati, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1397735065

    Chicago Manual of Style (17th edition)

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This open access ETD is published by University of Cincinnati and OhioLINK.