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The Neuroprotective Potential of Subthalamic Nucleus Deep Brain Stimulation in the 6-OHDA Rodent Model of Parkinson’s Disease

Spieles-Engemann, Anne L.
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1304692259

Abstract Details

2011, PhD, University of Cincinnati, Medicine: Neuroscience/Medical Science Scholars Interdisciplinary.
The studies in this dissertation are designed to examine the effects of subthalamic nucleus deep brain stimulation (STN DBS) in the 6-hydroxydopamine (6-OHDA) rodent model of Parkinson’s disease (PD). The first study examines whether STN DBS can provide neuroprotection to the dopaminergic neurons of the substantia nigra (SN) in the face of previous large-scale dopamine neuron loss, similar to what patients have upon initial diagnosis. The second study examines the effects of STN DBS on trophic factors within the STN itself and its target structures in both unlesioned and 6-OHDA lesioned animals. Findings from these studies demonstrate that STN DBS can provide neuroprotection to remaining dopaminergic neurons in the SN. Furthermore, the results show that STN DBS can upregulate brain-derived neurotrophic factor (BDNF) within the SN, striatum, globus pallidus interna, and M1 motor cortex. Taken together, these results demonstrate that STN DBS has the potential to be a disease-modifying therapy for PD, with important effects on cell survival and plasticity within the basal ganglia and motor cortex. They also suggest the need for further study of the use of STN DBS as a treatment for early stage PD as well as its use in other disorders in which downregulation of BDNF has been implicated. Finally, the more through understanding of STN DBS gained by these types of studies may aid in the risk-benefit analysis when deciding upon STN DBS as a treatment option.
James Herman, PhD (Committee Chair)
Michael Behbehani, PhD (Committee Member)
Timothy Collier, PhD (Committee Member)
Jack Lipton, PhD (Committee Member)
Fredy Revilla, MD (Committee Member)
Kim Seroogy, PhD (Committee Member)
Caryl Sortwell, PhD (Committee Member)
261 p.
Neurology
Parkinson's disease; Deep brain stimulation; Subthalamic nucleus; Neuroprotection; Trophic factors

Recommended Citations

Citations

  • Spieles-Engemann, A. L. (2011). The Neuroprotective Potential of Subthalamic Nucleus Deep Brain Stimulation in the 6-OHDA Rodent Model of Parkinson’s Disease [Doctoral dissertation, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1304692259

    APA Style (7th edition)

  • Spieles-Engemann, Anne. The Neuroprotective Potential of Subthalamic Nucleus Deep Brain Stimulation in the 6-OHDA Rodent Model of Parkinson’s Disease. 2011. University of Cincinnati, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1304692259.

    MLA Style (8th edition)

  • Spieles-Engemann, Anne. "The Neuroprotective Potential of Subthalamic Nucleus Deep Brain Stimulation in the 6-OHDA Rodent Model of Parkinson’s Disease." Doctoral dissertation, University of Cincinnati, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1304692259

    Chicago Manual of Style (17th edition)

ucin1304692259
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© 2010, some rights reserved.Creative Commons License The Neuroprotective Potential of Subthalamic Nucleus Deep Brain Stimulation in the 6-OHDA Rodent Model of Parkinson’s Disease by Anne L. Spieles-Engemann is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. Based on a work at etd.ohiolink.edu.
This open access ETD is published by University of Cincinnati and OhioLINK.