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Gene Expression Study and DNA Methylation Status of Aryl Hydrocarbon Receptor Gene in Rbf/f;Alb-Cre+ Mouse Liver Tumors

PENG, LI
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1186635329

Abstract Details

2007, MS, University of Cincinnati, Medicine : Toxicology (Environmental Health).
The aryl hydrocarbon receptor (AHR) is known primarily as a ligand-activated transcriptional activator that mediates the biologic and toxic effects of its xenobiotic ligands. AHR also has a role in cell cycle progression, and this function is accomplished in the absence of an exogenous ligand. However, the underlying mechanism is still unclear. The retinoblastoma tumor suppressor, RB, is absent or mutated in at least one-third of all human tumors. The specific mechanisms of tumor suppression by RB in discrete tissues are poorly defined. We investigated Ahr, Hdac1, Dnmt1, P15, P16, P18, P19, P21, P27, P53, Tgfβ1, Tgfβ2, Tgfβ3, Pai-1, Cyp1a1, Nqo1, Aldh3a at mRNA level in both Rbf/f and Rbf/f;Alb-Cre+ mouse liver tumor samples by real time PCR and Ahr DNA methylation status to understand the potential role of AHR in liver tumorigenesis.
Dr. Alvaro Puga (Advisor)
31 p.
aryl hydrocarbon receptor; retinoblastoma tumor suppressor; gene expression; DNA methylation

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Citations

  • PENG, L. (2007). Gene Expression Study and DNA Methylation Status of Aryl Hydrocarbon Receptor Gene in Rbf/f;Alb-Cre+ Mouse Liver Tumors [Master's thesis, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1186635329

    APA Style (7th edition)

  • PENG, LI. Gene Expression Study and DNA Methylation Status of Aryl Hydrocarbon Receptor Gene in Rbf/f;Alb-Cre+ Mouse Liver Tumors. 2007. University of Cincinnati, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1186635329.

    MLA Style (8th edition)

  • PENG, LI. "Gene Expression Study and DNA Methylation Status of Aryl Hydrocarbon Receptor Gene in Rbf/f;Alb-Cre+ Mouse Liver Tumors." Master's thesis, University of Cincinnati, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1186635329

    Chicago Manual of Style (17th edition)

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© 2007, all rights reserved.
This open access ETD is published by University of Cincinnati and OhioLINK.