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TWO SURFACE MODIFICATION METHODS TO REDUCE PROTEIN FOULING IN MICROFILTRATION MEMBRANES

RAJAM, SRIDHAR
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1172005034

Abstract Details

2007, MS, University of Cincinnati, Engineering : Chemical Engineering.
Protein fouling is a critical factor governing membrane performance in various filtration processes. In this study, we report two new surface modification techniques to modify 0.22greek small letter mu mixed cellulose esters membranes (MCE) and 0.20greek small letter mu, positively charged durapore membranes to reduce protein fouling. The first step in the modification of MCE membranes involves coating of the membrane with a monolayer of allyldimethylchlorosilane (ADCS). The silanized membrane is then covalently linked to Pluronic F127, a triblock copolymer of polyethylene oxide and polypropylene oxide (PEO–PPO–PEO) by UV irradiation at wavelengths >215 nm. The presence of PEO groups on the membrane surface increased the wettability of the membrane. Contact angle measurements confirmed that the degree of Pluronic grafting on the silanized membrane was a function of the UV exposure time. The hydraulic permeability and flux decline of the modified membrane during bovine serum albumin (BSA) filtration were nearly identical to the unmodified membrane. The modified membranes exhibited better cleaning characteristics compared to unmodified membranes upon back flushing with saline solution. The positively charged durapore membranes have been dip coated with random copolymers poly (oligoethylene glycol methacrylate co methacrylic acid), (OEGMA/MA), under four different conditions. The electrostatic adsorption of OEGMA/MA onto the membrane surface has been verified by streaming potential measurements. The ability of the modified membranes to resist protein adsorption has been verified by FTIR spectra. The hydraulic permeability and the flux decline data of the modified membranes were similar to the unmodified membranes and the cleaning characteristic of modified membranes showed improved performance.
Dr. Chia-Chi Ho (Advisor)
64 p.
Engineering, Chemical
Protein fouling; Microfiltration; graft coupling; Pluronic F127; OEGMA; allyldimethylchloro silane

Recommended Citations

Citations

  • RAJAM, S. (2007). TWO SURFACE MODIFICATION METHODS TO REDUCE PROTEIN FOULING IN MICROFILTRATION MEMBRANES [Master's thesis, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1172005034

    APA Style (7th edition)

  • RAJAM, SRIDHAR. TWO SURFACE MODIFICATION METHODS TO REDUCE PROTEIN FOULING IN MICROFILTRATION MEMBRANES. 2007. University of Cincinnati, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1172005034.

    MLA Style (8th edition)

  • RAJAM, SRIDHAR. "TWO SURFACE MODIFICATION METHODS TO REDUCE PROTEIN FOULING IN MICROFILTRATION MEMBRANES." Master's thesis, University of Cincinnati, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1172005034

    Chicago Manual of Style (17th edition)

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© 2006, all rights reserved.
This open access ETD is published by University of Cincinnati and OhioLINK.