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ucin1155826127.pdf (239.21 KB)
ETD Abstract Container
Abstract Header
HOST-[2] ROTAXANES: GUEST RECOGNITION AND CELLULAR TRANSPORT
Author Info
HOUSE, BRIAN EDWARD
Permalink:
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1155826127
Abstract Details
Year and Degree
2006, MS, University of Cincinnati, Arts and Sciences : Chemistry.
Abstract
There continues to be a great demand for synthetic hosts that recognize targeted guests as efficiently as proteins recognize endogenous ligands. Artificial protein mimetics could act as chemical sensors, catalysts, or agents that transport drugs across cell membranes. We have created new protein mimetics with amino acid recognition elements that converge to a hydrophobic pocket in order to provide maximum binding free energy with a guest. The dynamic component of these host-[2]rotaxanes allows them to adjust to their environment, whether aqueous or non-aqueous, and does not detract significantly from the binding free energy. The host-[2]rotaxanes bind a variety of biomolecules like oligopeptides and some of them efficiently transport fluorescein and some fluoresceinated peptides into eukaryotic cells.
Committee
Dr. David Smithrud (Advisor)
Pages
28 p.
Subject Headings
Chemistry, Biochemistry
Keywords
Rotaxane
;
Protein Mimetic
;
Molecular Recognition
;
Drug Transport
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Citations
HOUSE, B. E. (2006).
HOST-[2] ROTAXANES: GUEST RECOGNITION AND CELLULAR TRANSPORT
[Master's thesis, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1155826127
APA Style (7th edition)
HOUSE, BRIAN.
HOST-[2] ROTAXANES: GUEST RECOGNITION AND CELLULAR TRANSPORT.
2006. University of Cincinnati, Master's thesis.
OhioLINK Electronic Theses and Dissertations Center
, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1155826127.
MLA Style (8th edition)
HOUSE, BRIAN. "HOST-[2] ROTAXANES: GUEST RECOGNITION AND CELLULAR TRANSPORT." Master's thesis, University of Cincinnati, 2006. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1155826127
Chicago Manual of Style (17th edition)
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Document number:
ucin1155826127
Download Count:
538
Copyright Info
© 2006, all rights reserved.
This open access ETD is published by University of Cincinnati and OhioLINK.