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ucin1116270875.pdf (415.78 KB)
ETD Abstract Container
Abstract Header
THE EFFECTS OF NOISE EXPOSURE AT VARIOUS AGES ON AHL GENE EXPRESSION
Author Info
NOLTE, MANDEE L
Permalink:
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1116270875
Abstract Details
Year and Degree
2005, MA, University of Cincinnati, Allied Health Sciences : Audiology.
Abstract
C57BL/6J (B6) mice are the experimental model for presbycusis, and have been shown to be more susceptible to noise-induced hearing loss. The congenic B6-Cast mouse is genetically identical to the B6 strain, except that the Ahl gene has been replaced with a wild-type, gene for normal hearing. As a result, B6-Cast mice are thought to be resistant to the effects of aging and noise. The purpose of this study is to assess the effects of noise-exposure at specific ages on the expression of the Ahl gene. Results indicate that both strains of mice actually exhibit presbycusis and noise-induced hearing loss, but the B6-Cast strain develop hearing loss at a slower pace compared to the B6 strain. These results suggest that there is at least one other gene, other than Ahl, in the background of the B6 mice that contributes to the hearing losses experienced in this study.
Committee
Susan Stanton (Advisor)
Pages
39 p.
Keywords
C57BL/6J Mice
;
B6-Cast Mice
;
Ahl Gene
;
Presbycusis
;
noise-induced hearing loss
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Citations
NOLTE, M. L. (2005).
THE EFFECTS OF NOISE EXPOSURE AT VARIOUS AGES ON AHL GENE EXPRESSION
[Master's thesis, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1116270875
APA Style (7th edition)
NOLTE, MANDEE.
THE EFFECTS OF NOISE EXPOSURE AT VARIOUS AGES ON AHL GENE EXPRESSION.
2005. University of Cincinnati, Master's thesis.
OhioLINK Electronic Theses and Dissertations Center
, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1116270875.
MLA Style (8th edition)
NOLTE, MANDEE. "THE EFFECTS OF NOISE EXPOSURE AT VARIOUS AGES ON AHL GENE EXPRESSION." Master's thesis, University of Cincinnati, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1116270875
Chicago Manual of Style (17th edition)
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Document number:
ucin1116270875
Download Count:
678
Copyright Info
© 2005, all rights reserved.
This open access ETD is published by University of Cincinnati and OhioLINK.