Skip to Main Content
 

Global Search Box

 
 
 
 

Files

File List


ucin1080156678.pdf (1.5 MB)

ETD Abstract Container

Abstract Header

GluR5 IS INVOLVED IN REGULATION OF THE HPA AXIS

VAN HOOREN, DANIELLA CHRISTINE
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1080156678

Abstract Details

2004, MS, University of Cincinnati, Medicine : Interdisciplinary (Medical Science Scholars, Neuroscience).
Excitatory and inhibitory signals are summated at the paraventricular nucleus of the hypothalamus (PVN) and translated into a decision to initiate the hypothalamic pituitary adrenocortical (HPA) axis response to stress. The mechanism of action behind this initiation is still unknown, but the excitatory neurotransmitter glutamate is suspected to play a role. Glutamate receptors have been localized to PVN neurons. Ionotropic glutamate receptors (iGluRs) containing the GluR5 subunit have been localized to the region of the PVN known to initiate the HPA axis. The present study is a test of the hypothesis that iGluRs containing the GluR5 subunit are involved in activation of the HPA axis. We investigate this through microinfusion of a GluR5 agonist (ATPA), and antagonist (LY382884), directly into the PVN. We found that both LY382884 and ATPA activate the HPA axis, and suggest that these compounds may be functioning on fundamentally different receptors at different neuroanatomical locations.
Dr. James Herman (Advisor)
77 p.
Biology, Neuroscience
GluR5; Ionotropic Glutamate Receptors; Paraventricular Nucleus of the Hypothalamus (PVN); Corticotropin Releasing Hormone (CRH); Corticosterone; ACTH; HPA Axis

Recommended Citations

Citations

  • VAN HOOREN, D. C. (2004). GluR5 IS INVOLVED IN REGULATION OF THE HPA AXIS [Master's thesis, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1080156678

    APA Style (7th edition)

  • VAN HOOREN, DANIELLA. GluR5 IS INVOLVED IN REGULATION OF THE HPA AXIS. 2004. University of Cincinnati, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1080156678.

    MLA Style (8th edition)

  • VAN HOOREN, DANIELLA. "GluR5 IS INVOLVED IN REGULATION OF THE HPA AXIS." Master's thesis, University of Cincinnati, 2004. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1080156678

    Chicago Manual of Style (17th edition)

ucin1080156678
768
© 2004, all rights reserved.
This open access ETD is published by University of Cincinnati and OhioLINK.