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ucin1069702913.pdf (385.73 KB)
ETD Abstract Container
Abstract Header
ROLE OF THE AHR IN POLYBROMINATED BIPHENYL-INDUCED DEVELOPMENTAL TOXICITY
Author Info
MILLER, KEVIN ANTHONY
Permalink:
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1069702913
Abstract Details
Year and Degree
2003, MS, University of Cincinnati, Medicine : Environmental Health Sciences.
Abstract
PBBs are known to cause negative health effects in humans and in animals. It is unknown if these effects are mediated by an underlying genetic component of the AHR phenotype. In this study, we examined the developmental effects of both coplanar and noncoplanar PBBs on mouse lines having both high and low affinity AHR phenotype with C57BL/6J background. We determined a coplanar PBB high-affinity AHR-dependent neonatal lethality and immunotoxicity, coupled with the induction of CYP1A1 in embryonic liver and brain at gestational day 18.
Committee
Dr. Daniel W. Nebert (Advisor)
Pages
57 p.
Subject Headings
Health Sciences, Toxicology
Keywords
polybrominated biphenyls
;
Aryl hydrocarbon receptor
;
developmental toxicity
;
neonatal lethality
;
CYP1A1
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Citations
MILLER, K. A. (2003).
ROLE OF THE AHR IN POLYBROMINATED BIPHENYL-INDUCED DEVELOPMENTAL TOXICITY
[Master's thesis, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1069702913
APA Style (7th edition)
MILLER, KEVIN.
ROLE OF THE AHR IN POLYBROMINATED BIPHENYL-INDUCED DEVELOPMENTAL TOXICITY.
2003. University of Cincinnati, Master's thesis.
OhioLINK Electronic Theses and Dissertations Center
, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1069702913.
MLA Style (8th edition)
MILLER, KEVIN. "ROLE OF THE AHR IN POLYBROMINATED BIPHENYL-INDUCED DEVELOPMENTAL TOXICITY." Master's thesis, University of Cincinnati, 2003. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1069702913
Chicago Manual of Style (17th edition)
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Document number:
ucin1069702913
Download Count:
711
Copyright Info
© 2003, all rights reserved.
This open access ETD is published by University of Cincinnati and OhioLINK.