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BLOCKADE OF ECTOPIC ACTIVITY AT THE INITIAL STAGE OF PERIPHERAL NERVE INJURY PREVENTS NEUROPATHIC PAIN

XIE, WENRUI
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1057691866

Abstract Details

2003, PhD, University of Cincinnati, Medicine : Interdisciplinary (Medical Science Scholars, Neuroscience).
Following a nerve injury, there is evidence that there is a large increase in the level of spontaneous firing in the afferent neurons linked to the injury site. The development of this ectopic activity may be particularly important for the development of hyperalgesia, allodynia and ongoing pain associated with nerve injury. In the present study, the relationship between ectopic activity at the very beginning of peripheral nerve injury and neuropathic pain behavior (thermal hyperalgesia and mechanical allodynia) was examined. We used either chronic constriction injury (CCI) or spare nerve injury (SNI) on the sciatic nerve to produce neuropathic pain in rats. In some animals, the injured nerve activity was blocked initially with either bupivacaine or TTX for 5-7 days and 24 hours per day. Animal neuropathic pain behaviors, thermal hyperalgesia and mechanical alodynia, were checked from the first to 2 to 5 months post operation. During this time, there were no significant neuropathic pain behaviors observed on the rats with sciatic nerve injury and initial nerve blockade. We also checked the ectopic activity in rat sciatic nerve with CCI. Initial nerve blockade prevented the subsequent ectopic activity in injured nerve. However, 10 days following CCI or SNI, when rats already presented robust thermal hyperalgesia and mechanical allodynia, this blockade only relieved naturopathic pain temporarily during the blockade. These results suggested that ectopic activity occurring at the early stage of peripheral nerve injury was essential for the development of chronic neuropathic pain.
Dr. Lei Yu (Advisor)
202 p.
Biology, Neuroscience
ectopic activity; neuropathic pain; peripheral nerve injury

Recommended Citations

Citations

  • XIE, W. (2003). BLOCKADE OF ECTOPIC ACTIVITY AT THE INITIAL STAGE OF PERIPHERAL NERVE INJURY PREVENTS NEUROPATHIC PAIN [Doctoral dissertation, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1057691866

    APA Style (7th edition)

  • XIE, WENRUI. BLOCKADE OF ECTOPIC ACTIVITY AT THE INITIAL STAGE OF PERIPHERAL NERVE INJURY PREVENTS NEUROPATHIC PAIN. 2003. University of Cincinnati, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1057691866.

    MLA Style (8th edition)

  • XIE, WENRUI. "BLOCKADE OF ECTOPIC ACTIVITY AT THE INITIAL STAGE OF PERIPHERAL NERVE INJURY PREVENTS NEUROPATHIC PAIN." Doctoral dissertation, University of Cincinnati, 2003. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1057691866

    Chicago Manual of Style (17th edition)

ucin1057691866
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© 2003, all rights reserved.
This open access ETD is published by University of Cincinnati and OhioLINK.