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Effect of High Intensity Interval Training (HIIT) on Vascular Function and Insulin Sensitivity

Sugiura, Shinichiro
http://rave.ohiolink.edu/etdc/view?acc_num=toledo1430487607

Abstract Details

2015, Doctor of Philosophy, University of Toledo, Exercise Science.
High-intensity interval training (HIIT) is characterized by short bursts of vigorous physical activity, interspersed by periods of rest or low-intensity exercise of varying durations. HIIT may be used as an effective alternative to traditional endurance training, resulting in similar or greater improvements in a number of physiological, performance, and health-related indices in both healthy and in individuals with chronic diseases. The present thesis examined the effects of a two-week HIIT program on measures of aerobic fitness, vascular function (Chapter 3) and insulin sensitivity (Chapter 4). The first study demonstrated no effect on flow-mediated dilation or peak oxygen uptake following two weeks of HIIT with L-arginine supplement compared to HIIT alone, although both groups improved time to exhaustion and the peak work rate during progressive ramp exercise to fatigue. The results of the second study demonstrated six session of HIIT had no effect on glucose appearance and removal (i.e. oral glucose tolerance test, OGTT) or insulin sensitivity in healthy individuals with family history of type 2 diabetes mellitus (T2DM) or in healthy individuals without a family history of T2DM. However, results of the multiple regression analysis indicated that high density lipoprotein (HDL) and low density lipoprotein (LDL) significantly predicted insulin sensitivity in healthy individuals with a family history of T2DM. In order to prevent chronic diseases, such as T2DM, as well as other diseases that have a sedentary lifestyle as a primary risk factor, it is critical that individuals engage in regular physical activity in an effort to curb the rising trends in the prevalence of hypokinetic diseases. Although the results of the present investigation did not provide significant findings in this group of young, healthy adults, further investigations are necessary, including an examination of the physiological adaptations and compliance associated with longer term HIIT exercise programs, the inclusion of additional patient populations, and the optimal combination of exercise intensity, duration and recovery intervals in order to promote HIIT as an effective, efficient alternative training method.
Barry Scheuermann, Ph.D. (Committee Chair)
Suzanne Wambold, RN, Ph.D. (Committee Member)
Abraham Lee, PT, Ph.D. (Committee Member)
David Weldy , MD, Ph.D. (Committee Member)
195 p.
Health Sciences
High Intensity Interval Training, Flow-Mediated Dilation, Family History of Type 2 Diabetes Mellitus, Insulin Sensitivity

Recommended Citations

Citations

  • Sugiura, S. (2015). Effect of High Intensity Interval Training (HIIT) on Vascular Function and Insulin Sensitivity [Doctoral dissertation, University of Toledo]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1430487607

    APA Style (7th edition)

  • Sugiura, Shinichiro . Effect of High Intensity Interval Training (HIIT) on Vascular Function and Insulin Sensitivity . 2015. University of Toledo, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=toledo1430487607.

    MLA Style (8th edition)

  • Sugiura, Shinichiro . "Effect of High Intensity Interval Training (HIIT) on Vascular Function and Insulin Sensitivity ." Doctoral dissertation, University of Toledo, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1430487607

    Chicago Manual of Style (17th edition)

toledo1430487607
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This open access ETD is published by University of Toledo and OhioLINK.