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Full text release has been delayed at the author's request until May 15, 2026

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Effects of Nuclear PTHrP on Growth Hormone IGF1-Axis in the Liver

Turner, Megan M.
http://rave.ohiolink.edu/etdc/view?acc_num=ouhonors1714090554686017

Abstract Details

2024, Bachelor of Science (BS), Ohio University, Biological Sciences.
Parathyroid hormone-related protein (PTHrP) is a hormone originally discovered in cancer patients as a cause of cancer-associated hypercalcemia. PTHrP was then unexpectedly found to be in many normal tissues of the body. PTHrP is similar in function and structure to the well-known hormone, parathyroid hormone (PTH). Previous studies showed that removing the nuclear localization sequence (NLS) and the C-terminus domains of PTHrP in mice (PTHrP 1- 66) caused severe abnormalities including lack of skeletal formation and decreased hematopoiesis (Toribio et al., 2010). These mice usually die within 5 days. Due to the dwarfism of these mice, this thesis explores the relationship of how reduced PTHrP affects the growth hormone (GH) and insulin-like growth factor 1 (IGF-1) axis in the liver of mice. Using quantitative polymerase chain reaction (qPCR) and RNA-sequencing, we found that IGF-1 was decreased in the liver and serum. We also found that GH in serum and its mRNA was normal to increased. The RNA-seq data also showed that the growth hormone receptor (GHR) was slightly downregulated, but genes downstream from the GHR were variably modified. Unexpectedly, the RNA-seq data showed that the most downregulated pathway was the cell cycle pathway.
Thomas J. Rosol (Advisor)
50 p.
Biology
PTHrP; IGF-1; GH; growth hormone; parathyroid hormone

Recommended Citations

Citations

  • Turner, M. M. (2024). Effects of Nuclear PTHrP on Growth Hormone IGF1-Axis in the Liver [Undergraduate thesis, Ohio University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ouhonors1714090554686017

    APA Style (7th edition)

  • Turner, Megan. Effects of Nuclear PTHrP on Growth Hormone IGF1-Axis in the Liver. 2024. Ohio University, Undergraduate thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ouhonors1714090554686017.

    MLA Style (8th edition)

  • Turner, Megan. "Effects of Nuclear PTHrP on Growth Hormone IGF1-Axis in the Liver." Undergraduate thesis, Ohio University, 2024. http://rave.ohiolink.edu/etdc/view?acc_num=ouhonors1714090554686017

    Chicago Manual of Style (17th edition)

ouhonors1714090554686017
© 2024, all rights reserved.
This open access ETD is published by Ohio University Honors Tutorial College and OhioLINK.
Release 3.2.12