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The Effects of Ionizing Radiation on Integrin-Mediated Adhesion of Breast Cancer Cells

Zimmerman, Amy L.
http://rave.ohiolink.edu/etdc/view?acc_num=ouhonors1306255509

Abstract Details

2011, Bachelor of Science (BS), Ohio University, Chemistry.
There were over 207,000 new cases of invasive breast cancer and nearly 40,000 deaths from the disease in the U.S. in 2010. It is, therefore, critical to develop a better understanding of the disease process. Invasive cancer is marked by the loss of integrity of the basement membrane of a tissue, a specialized form of extracellular matrix (ECM) that normally separates a tissue from its surroundings; however, a complex, dynamic interaction involving many overlapping signaling pathways exists between breast tissue and its neighboring ECM. Invasion is initiated when the tumor cells have increased adhesion to the ECM, which is mainly modulated by interactions with the integrin family of adhesion proteins on the surface of the tumor cells. Each integrin heterodimer has a different adhesive affinity for each of the ECM proteins, namely fibronectin, vitronectin, collagen I, and collagen IV. This project examined the relative expression of integrins following exposure to ionizing radiation, which is commonly used for cancer therapy. Ionizing radiation forms free radicals and reactive oxygen species, which then cause damage within the cell. Although the exact mechanism is unknown, the hypothesis of this study was that exposure to high dose ionizing radiation would change the expression of the integrins and change integrin-mediated adhesion to the ECM proteins. Results showed that in the MDA-MB-231 cell line, ionizing radiation induces significant changes in both integrin expression and integrin-mediated adhesion to fibronectin, laminin, and collagens I and IV. After gathering further evidence from this and other cell lines, this information could potentially be used to optimize treatment for patients with invasive cancers.
Shiyong Wu, PhD (Advisor)
38 p.
Biochemistry; Biomedical Research; Cellular Biology; Chemistry
breast cancer; integrins; adhesion; ionizing radiation

Recommended Citations

Citations

  • Zimmerman, A. L. (2011). The Effects of Ionizing Radiation on Integrin-Mediated Adhesion of Breast Cancer Cells [Undergraduate thesis, Ohio University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ouhonors1306255509

    APA Style (7th edition)

  • Zimmerman, Amy. The Effects of Ionizing Radiation on Integrin-Mediated Adhesion of Breast Cancer Cells. 2011. Ohio University, Undergraduate thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ouhonors1306255509.

    MLA Style (8th edition)

  • Zimmerman, Amy. "The Effects of Ionizing Radiation on Integrin-Mediated Adhesion of Breast Cancer Cells." Undergraduate thesis, Ohio University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=ouhonors1306255509

    Chicago Manual of Style (17th edition)

ouhonors1306255509
462
© 2011, all rights reserved.
This open access ETD is published by Ohio University Honors Tutorial College and OhioLINK.