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A comparison of multiplicity adjustment methods for three-arm treatment plus trials

Kuang, Zhanpeng
http://rave.ohiolink.edu/etdc/view?acc_num=osu1732492663399616

Abstract Details

2024, Master of Science, Ohio State University, Public Health.
Multi-arm trials are common among randomized controlled trials. These parallel-group trials compare three or more interventions, usually to a shared control. Our simulation study focuses on a specific multi-arm structure – one that involves three arms: control, treatment, and treatment plus. Due to the potential number of comparisons that investigators can conduct under this three-arm structure, the issue of multiple comparisons must be considered. For a three-arm treatment plus trial, seven methods were explored: Bonferroni, Holm, Hochberg, fixed sequence, hierarchy, Dunnett, and Prospective Alpha Allocation Scheme (PAAS). To directly compare these procedures with one another, a simulation study was conducted to determine which method controlled FWER at α = 0.05 while maximizing power. Power for each method was calculated as sample sizes, allocation schemes, prevalences and effect sizes were changed. Overall, we saw that all seven methods could maintain the expected α = 0.05 type I error rate. Dunnett generally performed the worst and was not recommended as a solution. Bonferroni, Holm, Hochberg, and PAAS were comparable in power while fixed sequence and hierarchy varied depending on allocation ratio.
Rebecca Andridge (Committee Member)
Abigail Shoben (Advisor)
Biostatistics
multiple comparisons; clinical trials

Recommended Citations

Citations

  • Kuang, Z. (2024). A comparison of multiplicity adjustment methods for three-arm treatment plus trials [Master's thesis, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1732492663399616

    APA Style (7th edition)

  • Kuang, Zhanpeng. A comparison of multiplicity adjustment methods for three-arm treatment plus trials. 2024. Ohio State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1732492663399616.

    MLA Style (8th edition)

  • Kuang, Zhanpeng. "A comparison of multiplicity adjustment methods for three-arm treatment plus trials." Master's thesis, Ohio State University, 2024. http://rave.ohiolink.edu/etdc/view?acc_num=osu1732492663399616

    Chicago Manual of Style (17th edition)

osu1732492663399616
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This open access ETD is published by The Ohio State University and OhioLINK.