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Full text release has been delayed at the author's request until May 05, 2026

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Innate Immune Control Mechanisms for Influenza B Virus

Scace, Sydney
http://rave.ohiolink.edu/etdc/view?acc_num=osu1713276887135588

Abstract Details

2024, Master of Science, Ohio State University, Immunology and Microbial Pathogenesis.
Influenza B virus circulates seasonally in humans and primarily affects young children, the elderly, and the immunocompromised with 290,000-650,000 influenza B related deaths annually. The cellular protein interferon induced transmembrane protein 3 (IFITM3) is known to restrict several virus infections by altering endosomal membrane properties in a manner that prevents virus-to-cell membrane fusion reactions. IFITM3 is particularly beneficial in limiting the severity of influenza A virus infection in humans and mice, though whether it inhibits influenza B virus infections of cells or pathogenesis in vivo is not well studied. We thus sought to investigate the role of IFITM3 in influenza B virus infections in human cells and using the mouse model. From my work using influenza B virus in vitro with IFITM3 deficient and IFITM3 overexpressing cell models, and in vivo with wild type and IFITM3 knockout mice, we conclude that IFITM3 restricts influenza B virus infections of cells and pathogenesis in vivo.
Jacob Yount (Advisor)
40 p.
Immunology; Virology

Recommended Citations

Citations

  • Scace, S. (2024). Innate Immune Control Mechanisms for Influenza B Virus [Master's thesis, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1713276887135588

    APA Style (7th edition)

  • Scace, Sydney. Innate Immune Control Mechanisms for Influenza B Virus. 2024. Ohio State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1713276887135588.

    MLA Style (8th edition)

  • Scace, Sydney. "Innate Immune Control Mechanisms for Influenza B Virus." Master's thesis, Ohio State University, 2024. http://rave.ohiolink.edu/etdc/view?acc_num=osu1713276887135588

    Chicago Manual of Style (17th edition)

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© 2024, all rights reserved.
This open access ETD is published by The Ohio State University and OhioLINK.