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BRCAShare: The Impact of Familial Communication Guide and Video Interventions on Intra-Familial Sharing of Genetic Test Results

Riefski, Katie
http://rave.ohiolink.edu/etdc/view?acc_num=osu1713274472682851

Abstract Details

2024, Master of Science, Ohio State University, Genetic Counseling.
Cascade testing for Hereditary Breast and Ovarian Cancer syndrome (HBOC) is central to identifying family members at heightened risk for cancer. Despite the well-documented importance of cascade testing, such as the United States Centers for Disease Control and Prevention and Office of Public Health Genomics naming HBOC a Tier 1 Genomics Application, current data suggest that the uptake of cascade testing remains suboptimal (Fehniger et al., 2013; Menko et al., 2019). There are many cited barriers to family discussion of HBOC and cascade testing, and research suggests that healthcare providers can alleviate certain barriers by providing informational resources to facilitate patient-mediated communication (Chivers Seymour et al., 2010; Srinivasan et al., 2020, Frey et al., 2022). In this survey-based study, 103 individuals with a likely pathogenic or pathogenic variant in BRCA1 or BRCA2 were recruited. We assessed the reactions to and impact of a 2-minute animated video (BRCAShare), in conjunction with a family communication guide, on the intrafamilial sharing of genetic test results. The BRCAShare video, guided by the Health Belief Model (HBM), depicts a hypothetical scenario of a relative’s recent diagnosis of HBOC. Surveys assessed three domains from enrollment to post-study: 1) participants’ intent to share; 2) perceived susceptibility, seriousness, benefits, or barriers to intrafamilial sharing of results and cascade testing; 3) the impact of family dynamic on sharing. All participants received the electronic family communication guide, while only one randomized group received the BRCAShare video in addition to the communication guide. Those who viewed the video had significantly higher odds of reporting intent to share compared to those who did not, suggesting that a video message is an effective method for increasing family communication about HBOC and cascade testing (p<0.05). Results also suggest that participants who viewed the video perceived sharing to be easier and less time-consuming than those who did not. While perceptions of HBOC did not change significantly after viewing the BRCAShare video, at baseline, participants demonstrated strong understanding of the risks of HBOC and benefits of genetic testing. Interestingly, 59% of video viewers agreed that their relative would be thankful to be notified, reinforcing the previously studied idea of an at-risk relative’s persisting gratitude for being informed, despite other possible negative reactions they may have (Aeilts et al., 2021). While this study did not identify a significant association between family dynamics and more intent to share, family cohesiveness is believed to be important in the discussion of cascade testing (Fehniger et al., 2013). Therefore, it is important to consider that a single informational resource may not fit the unique communication styles of all families with HBOC, and families with high relative cohesiveness may prefer more direct communication.
Leigha Senter-Jamieson (Advisor)
Alexandra Spencer (Committee Member)
Amber Aeilts (Committee Member)
67 p.
Genetics; Oncology
genetics; cancer genetics; BRCA; genetic testing; cascade testing

Recommended Citations

Citations

  • Riefski, K. (2024). BRCAShare: The Impact of Familial Communication Guide and Video Interventions on Intra-Familial Sharing of Genetic Test Results [Master's thesis, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1713274472682851

    APA Style (7th edition)

  • Riefski, Katie. BRCAShare: The Impact of Familial Communication Guide and Video Interventions on Intra-Familial Sharing of Genetic Test Results. 2024. Ohio State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1713274472682851.

    MLA Style (8th edition)

  • Riefski, Katie. "BRCAShare: The Impact of Familial Communication Guide and Video Interventions on Intra-Familial Sharing of Genetic Test Results." Master's thesis, Ohio State University, 2024. http://rave.ohiolink.edu/etdc/view?acc_num=osu1713274472682851

    Chicago Manual of Style (17th edition)

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This open access ETD is published by The Ohio State University and OhioLINK.