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Full text release has been delayed at the author's request until December 18, 2024

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Fluctuations in Heart Rate Influence Cardiac Arrhythmic Propensity: A Translational Investigation

Phadumdeo, Vrishti Mohini
http://rave.ohiolink.edu/etdc/view?acc_num=osu1701269962077641

Abstract Details

2023, Doctor of Philosophy, Ohio State University, Biomedical Engineering.
Heart rate constantly fluctuates from beat-to-beat on a timescale ranging from seconds to hours under physiological conditions, termed heart rate variability (HRV). Clinical studies have shown that reduced HRV correlates with an increased risk for cardiac arrhythmias in various diseases, like chronic heart failure (CHF). HRV also influences the formation of pro-arrhythmic alternans, a beat-to-beat alternation in intracellular calcium (Ca) levels or the action potential duration (APD), which can form at different spatial scales. In this thesis, I investigate the impact of fluctuations in heart rate on alternans formation and arrhythmic propensity in various physiological and pathological conditions. I show that high HRV has anti-arrhythmic effects, such as mitigating the effects of subcellular Ca alternans formation. I also generate long-term, patient-specific simulations using patient RR sequences and a normal sinus rhythm and CHF model and demonstrate that both specific changes in heart rate and CHF-associated remodeling influence APD alternans formation. Finally, I examine the relationship between changes in RR sequence statistical properties and arrhythmia formation in Dravet Syndrome, a type of genetic epilepsy. My results suggest that the time course of response to epinephrine/caffeine treatment is a potential biomarker for arrhythmia-related Sudden Unexpected Death in Epilepsy in Dravet Syndrome.
Seth Weinberg (Advisor)
Rengasayee Veeraraghavan (Committee Member)
Thomas Hund (Committee Member)
186 p.
Biomedical Engineering; Medicine; Physiology
Heart Rate Variability; Chronic Heart Failure

Recommended Citations

Citations

  • Phadumdeo, V. M. (2023). Fluctuations in Heart Rate Influence Cardiac Arrhythmic Propensity: A Translational Investigation [Doctoral dissertation, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1701269962077641

    APA Style (7th edition)

  • Phadumdeo, Vrishti. Fluctuations in Heart Rate Influence Cardiac Arrhythmic Propensity: A Translational Investigation. 2023. Ohio State University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1701269962077641.

    MLA Style (8th edition)

  • Phadumdeo, Vrishti. "Fluctuations in Heart Rate Influence Cardiac Arrhythmic Propensity: A Translational Investigation." Doctoral dissertation, Ohio State University, 2023. http://rave.ohiolink.edu/etdc/view?acc_num=osu1701269962077641

    Chicago Manual of Style (17th edition)

osu1701269962077641
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This open access ETD is published by The Ohio State University and OhioLINK.