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Full text release has been delayed at the author's request until May 08, 2025

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Investigating the Degradation Profile of Novel TEVG Polymeric Scaffolds

Anderson, Cole
http://rave.ohiolink.edu/etdc/view?acc_num=osu1681909363021152

Abstract Details

2023, Master of Science, Ohio State University, Biomedical Engineering.
Development of Tissue-Engineered Vascular Grafts (TEVG’s) for use in treatment of pediatric cardiovascular disease offer a promising alternative to current synthetic graft models, which typically result in the patient needing additional surgeries to correct for complications related to the inability of these grafts to assimilate into the body. Understanding this potential for TEVG performance improvement, we saw opportunity in optimizing the scaffolds design. Herein, we utilized an accelerated degradation mechanism in a basic environment to begin to characterize the degradation space of our six novel scaffold variants: comparing their microstructure, chemical composition, and mechanical integrity at nine different timepoints (Day 0 (control), 1, 3, 5, 7, and 9) to our clinical TEVG scaffold. Current analyses have shown differing chemical compositions of PGA, PLA, and PCL for each scaffold at baseline (day 0), as well as similarities and differences between mechanical and microstructural characteristics of each scaffold variant. While initial degradation of samples is complete, data collection and analysis for this study is ongoing. Once complete, this data will be applied to a multiscale fluid-solid growth (mFSG) computational model that can identify future scaffold designs for optimizing the microstructure, degradation rate, and mechanical profile of the TEVG polymeric scaffold.
Daniel Gallego-Perez (Committee Member)
Christopher Breuer (Advisor)
44 p.
Biomedical Engineering
Tissue Engineering; Regenerative Medicine, Biomedical Engineering; Biomaterials

Recommended Citations

Citations

  • Anderson, C. (2023). Investigating the Degradation Profile of Novel TEVG Polymeric Scaffolds [Master's thesis, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1681909363021152

    APA Style (7th edition)

  • Anderson, Cole. Investigating the Degradation Profile of Novel TEVG Polymeric Scaffolds. 2023. Ohio State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1681909363021152.

    MLA Style (8th edition)

  • Anderson, Cole. "Investigating the Degradation Profile of Novel TEVG Polymeric Scaffolds." Master's thesis, Ohio State University, 2023. http://rave.ohiolink.edu/etdc/view?acc_num=osu1681909363021152

    Chicago Manual of Style (17th edition)

osu1681909363021152
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This open access ETD is published by The Ohio State University and OhioLINK.