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The Epidemiological Trends of Drug-Related Overdose Hospitalizations in Florida, 1988-2012

Griggs, Vanessa
http://orcid.org/0000-0002-3365-441X
http://rave.ohiolink.edu/etdc/view?acc_num=osu1671629876935222

Abstract Details

2023, Doctor of Philosophy, Ohio State University, Public Health.
Drug-related overdoses are the leading cause of injury-related death in the United States. Previous drug overdose research has focused primarily on death-related outcomes and opioid-related overdoses. Currently, little is known about drug-related hospitalizations and non-opioid-related overdoses. A drug overdose occurs when a toxic amount of a drug or drugs overwhelms a person’s body, limiting normal body functions. A better understanding of drug-related hospitalizations and ecological associations will aid in interventions and policy creation to lessen the severity of the Florida drug epidemic, and possibly the US drug epidemic. In this research project, I analyzed an extensive database of more than 63 million inpatient hospital billing records from all Florida hospitals collected by the Agency for Health Care Administration in Florida (AHCAF) from 1988 to 2012. The overall objective of this study was to elucidate trends and patterns of hospitalizations for drug-related overdoses during the study period. There were four specific aims of this study: examine epidemiological trends of drug-related overdose hospitalizations in Florida between 1988 and 2012, explore risk factors for predicting an intensive care unit admission during a drug-related overdose hospitalization in Florida from 2010 to 2012, examine the association between county-level demographics and county-level drug-related overdose hospitalization rates in Florida in 2010, and compare comorbid psychiatric condition profiles between Florida residents discharged to home and psychiatric care after a drug-related overdose hospitalization in 2010. Over the 25 years of the study, drug-related overdose hospitalization rates increased significantly for opioids and analgesics (908%), sedatives and hypnotics (38%), psychotropic agents (27%), and central nervous system stimulants (4550%). During the same period, the hospitalization rates due to central nervous system depressants and anesthetics decreased by 41% over time. For opioid-related hospitalizations, the most substantial proportion of those hospitalized were aged 45-54 years old (22.6%), non-Hispanic whites (85.9%), and females (52.2%). Approximately 54% of drug-related overdose hospitalization in Florida from 2010 to 2012 were admitted to the ICU. Multivariate logistic regression and random forest modeling techniques identified risk factors associated with ICU admissions during a drug-related overdose hospitalization. Both models identified similar risk factors associated with ICU admissions race, opioid use, insurance status, and facility region. Random forest modeling was comparable to logistic regression based on accuracy and discrimination (AUC). There was no association between the density of psychiatrists within counties and drug-related overdose hospitalization. Notably, over 96% of those discharged to psychiatric care had at least one diagnosed mental health disorder, and approximately 89% of those discharged to home had at least one diagnosed mental health disorder. The top mental disorders diagnosed included: nondependent misuse of drugs (57.0%); episodic mood disorders (39.1%); anxiety, dissociative and somatoform disorders (21.2%); depressive disorders (15.7%); and drug dependence (12.9%). More than half (52.3%) of patients had at least two mental health disorders diagnosed during their drug-related hospitalization. The overall results of this research project provide insight into the epidemiological trends and risk factors associated with drug-related hospitalizations. Knowing these risk factors allows for intervention programs to target high-risk populations. It also gives legislators additional background when designing and implementing programs, like Florida’s Prescription Drug Monitoring Program.
Randall Harris (Advisor)
Jared Huling (Committee Member)
Kathyrn Lancaster (Committee Member)
Tasleem Padamsee (Committee Member)
311 p.
Public Health; Public Policy
Drug overdose, opioids, substance misuse disorder, hospitalizations, public health

Recommended Citations

Citations

  • Griggs, V. (2023). The Epidemiological Trends of Drug-Related Overdose Hospitalizations in Florida, 1988-2012 [Doctoral dissertation, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1671629876935222

    APA Style (7th edition)

  • Griggs, Vanessa. The Epidemiological Trends of Drug-Related Overdose Hospitalizations in Florida, 1988-2012. 2023. Ohio State University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1671629876935222.

    MLA Style (8th edition)

  • Griggs, Vanessa. "The Epidemiological Trends of Drug-Related Overdose Hospitalizations in Florida, 1988-2012." Doctoral dissertation, Ohio State University, 2023. http://rave.ohiolink.edu/etdc/view?acc_num=osu1671629876935222

    Chicago Manual of Style (17th edition)

osu1671629876935222
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© 2023, some rights reserved.Creative Commons License The Epidemiological Trends of Drug-Related Overdose Hospitalizations in Florida, 1988-2012 by Vanessa Griggs is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. Based on a work at etd.ohiolink.edu.
This open access ETD is published by The Ohio State University and OhioLINK.