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Brady MSThesis Final 2nd.pdf (717.42 KB)

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Abdominal Aortic Sonography as a Cardiovascular Disease Risk Assessment

Brady, Austin
http://rave.ohiolink.edu/etdc/view?acc_num=osu166073579234338

Abstract Details

2022, Master of Science, Ohio State University, Health and Rehabilitation Sciences.
Cardiovascular disease (CVD) is a group of disorders affecting the heart and blood vessels. This insidious pathology is the leading cause of death in the United States, accounting for 868,662 deaths in 2017. The prevalence of this disease is expected to increase, with 45.1% of the population expected to have some form of CVD by 2035. Aside from the growing health concern, CVD is also the costliest chronic disease in the country, projected to hit 1.1 trillion dollars in total cost by 2035. This information underscores the importance of advancing CVD detection and primary prevention. Current CVD risk assessment usually relies on clinical prediction models that estimate a patient’s risk of having a CVD event in the future. The most recent recommendation for assessing risk of CVD in asymptomatic populations, is the use of the pooled cohort equations (PCE) atherosclerotic cardiovascular disease (ASCVD) risk estimator. Many patients who are evaluated using these clinical prediction models end up needing a more refined risk assessment to develop the most appropriate care plan. For this purpose, coronary artery calcium (CAC) scoring with computed tomography is the most widely used. While these tools are well validated, they are not without limitations. The need for new, non-invasive, accessible, relatively inexpensive, and low-risk CVD assessment tools is vital to further improve detection and prevention. This project explored the use of abdominal aortic sonography for use as a CVD risk assessment tool. Participants provided their imaging and health data in order to both evaluate the feasibility of using sonography to assess atherosclerotic plaque burden in the abdominal aorta, and explore associations between the imaging data and traditional CVD risk factors. After developing an imaging protocol and novel grading system, abdominal aortic sonography was proven to be a reliable, and practical method of measuring atherosclerotic burden in the inferior portion of the aorta. Statistically significant moderate associations were found between sonographic measures of atherosclerosis and several traditional CVD risk factors. Abdominal aortic sonography is a practical, accessible, and relatively low cost diagnostic tool, but further research is needed to definitively prove it can be appropriate for improving risk assessment of CVD.
Nicholas Funderburg, Ph.D. (Advisor)
Christopher Taylor, Ph.D. (Committee Member)
Kevin Evans, Ph.D. (Committee Member)
Health Care; Medical Imaging; Radiology

Recommended Citations

Citations

  • Brady, A. (2022). Abdominal Aortic Sonography as a Cardiovascular Disease Risk Assessment [Master's thesis, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu166073579234338

    APA Style (7th edition)

  • Brady, Austin. Abdominal Aortic Sonography as a Cardiovascular Disease Risk Assessment. 2022. Ohio State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu166073579234338.

    MLA Style (8th edition)

  • Brady, Austin. "Abdominal Aortic Sonography as a Cardiovascular Disease Risk Assessment." Master's thesis, Ohio State University, 2022. http://rave.ohiolink.edu/etdc/view?acc_num=osu166073579234338

    Chicago Manual of Style (17th edition)

osu166073579234338
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