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Intravenous Ketamine Infusions for Chronic Oral and Maxillofacial Pain Disorders. A Systematized Review

Hurd, Matthew
http://orcid.org/0000-0002-2248-2675
http://rave.ohiolink.edu/etdc/view?acc_num=osu1646053663606799

Abstract Details

2022, Master of Science, Ohio State University, Dentistry.
Chronic oral and maxillofacial pain conditions represent a diverse group of disorders. Broadly, they can be broken down into temporomandibular disorders (TMDs) and/or orofacial pain disorders. These classifications further detail a series of conditions ranging from joint pains, muscles pains, headaches, to various neuralgias of the head, neck, and face. The presence of depression often complicates these conditions. In addition, chronic noxious stimuli can lead to central sensitization, amplifying and protracting pain. Ketamine, a commonly used general anesthetic agent, has been studied in pre-clinical animal and human clinical trials and has shown great promise for treating chronic pain and depression. It has also been proposed that intravenous ketamine administration plays a role in reversing central sensitization. Albeit simplified, the hypothesized mechanism of action behind ketamine’s ability to perform these actions primarily lies within the drug’s ability to inhibit N-methyl-D-aspartate receptors (NMDAR) in the central nervous system. However, it is thought that other factors are at play behind ketamine’s clinically valuable attributes. Unfortunately, most research in this field has been studied without regard to the head, neck, and face. The following is a systematized review of ketamine therapy to treat such disorders. Regrettably, the results demonstrated the dental profession's lack of pursuit in ketamine therapy when treating chronic oral and maxillofacial pain patients. Nevertheless, there was a meaningful amount of data covering the utility of ketamine therapy. Although most clinical trials present with large degrees of design heterogenicity, the overwhelming conclusion of these publications suggests great promise for the use of intravenous ketamine infusions to treat a multitude of chronic pain conditions. Given these results, the dental profession, with its recent addition of two new specialties (i.e., dental anesthesiology and orofacial pain), alongside those in dentistry who have been diagnosing and treating these patients for years (e.g., oral surgeons, general dentist, etc.), is primed with a unique set of clinical knowledge and knowhow to follow suit. Dentistry has the opportunity to pursue and translate the current literature and research into evidence-based practices for chronic oral and maxillofacial pain conditions.
Bryant Cornelius (Advisor)
Gregory Ness (Committee Member)
William Johnston (Committee Member)
Erin Gross (Committee Member)
83 p.
Dental Care; Dentistry
Ketamine; Intravenous Ketamine; Ketamine Infusion; Chronic Pain; Chronic Dental Pain; Dental Pain; Temporomandibular Disorders; TMD; Orofacial Pain; Chronic Orofacial Pain; Chronic TMD; Chronic Temporomandibular Disorders; Ketamine for Chronic Dental Pain; Ketamine Infusion for Chronic Dental Pain; Ketamine in Dentistry

Recommended Citations

Citations

  • Hurd, M. (2022). Intravenous Ketamine Infusions for Chronic Oral and Maxillofacial Pain Disorders. A Systematized Review [Master's thesis, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1646053663606799

    APA Style (7th edition)

  • Hurd, Matthew. Intravenous Ketamine Infusions for Chronic Oral and Maxillofacial Pain Disorders. A Systematized Review. 2022. Ohio State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1646053663606799.

    MLA Style (8th edition)

  • Hurd, Matthew. "Intravenous Ketamine Infusions for Chronic Oral and Maxillofacial Pain Disorders. A Systematized Review." Master's thesis, Ohio State University, 2022. http://rave.ohiolink.edu/etdc/view?acc_num=osu1646053663606799

    Chicago Manual of Style (17th edition)

osu1646053663606799
529
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This open access ETD is published by The Ohio State University and OhioLINK.