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Final Dissertation.pdf (71.74 MB)

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Overcoming Barriers in the Adoption of Tissue Engineered Devices in the Field of Regenerative Medicine

Chang, Yu-Chun
http://rave.ohiolink.edu/etdc/view?acc_num=osu1641401579626525

Abstract Details

2022, Doctor of Philosophy, Ohio State University, Biomedical Sciences.
Regenerative medicine has the potential to revolutionize the field of surgical medicine. More specifically, tissue-engineered vascular grafts (TEVGs) offer a promising solution to current challenges associated with the use of synthetic conduits in cardiac diseases. Since its first use in humans back in 1999 numerous advances have been made describing the remodeling, performance, and outcomes of TEVGs; however, the barriers to its widespread adoption remain largely the same. First, there remains a tendency for the lumen of TEVGs to narrow due to excessive tissue formation. Second, an issue broadly implicated within the field of cardiothoracic surgery, is the development of adhesions following repeat operations thus hindering access and function. This dissertation seeks to overcome both issues through the application of novel therapeutic agents. The findings reported further advance mechanistic knowledge of the regenerative process that may one day improve outcomes of associated with tissue engineering.
Christopher Breuer (Advisor)
Philip Binkley (Committee Member)
Jeffrey Parvin (Committee Member)
99 p.
Biology; Biomedical Engineering; Biomedical Research; Cellular Biology; Medicine
tissue engineering; regenerative medicine; tissue engineered vascular grafts; macrophage; zoledronate; bisphosphonates; adhesions; myocardial infarction

Recommended Citations

Citations

  • Chang, Y.-C. (2022). Overcoming Barriers in the Adoption of Tissue Engineered Devices in the Field of Regenerative Medicine [Doctoral dissertation, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1641401579626525

    APA Style (7th edition)

  • Chang, Yu-Chun. Overcoming Barriers in the Adoption of Tissue Engineered Devices in the Field of Regenerative Medicine. 2022. Ohio State University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1641401579626525.

    MLA Style (8th edition)

  • Chang, Yu-Chun. "Overcoming Barriers in the Adoption of Tissue Engineered Devices in the Field of Regenerative Medicine." Doctoral dissertation, Ohio State University, 2022. http://rave.ohiolink.edu/etdc/view?acc_num=osu1641401579626525

    Chicago Manual of Style (17th edition)

osu1641401579626525
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