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Full text release has been delayed at the author's request until May 10, 2026
ETD Abstract Container
Abstract Header
Dynamic DNA Origami Assemblies for Signal Transmission
Author Info
Serrano Paladines, Andres
Permalink:
http://rave.ohiolink.edu/etdc/view?acc_num=osu1610037074511565
Abstract Details
Year and Degree
2021, Master of Science, Ohio State University, Mechanical Engineering.
Abstract
Scaffolded DNA origami has emerged as a prevalent technique for the design and construction of nanostructures of specific size, geometry, and function. Specifically, this technology enables programming nanostructure functionality by defining structural, mechanical and dynamic properties. Recent advancements have focused on integrating individual dynamic nanostructures to create reconfigurable supramolecular systems. Subsequently, these functional systems can be triggered by biological or environmental inputs to undergo conformational changes capable of reconfiguring other materials, providing measurable readouts, or influencing biological processes. This work aims to expand on dynamic functions by developing a reconfigurable assembly where local conformational changes can be physically communicated to other parts of the assembly through cascaded motion. We have designed a dynamic DNA nanostructure that can be assembled into arrays that can reach length scales ~10-100 times larger than the individual structure. We have demonstrated proof-of-concept for propagating conformational changes across nanodevices. DNA strands specific to one end of the array initiate motion for the “trigger” structure at that end, which in turn propagates motion to a neighboring structure, and so on in a sequential manner. This propagated motion is designed to transmit a signal across large distances. Creating programmable hierarchical assemblies capable of driving directional motion or signal has become a key goal in DNA nanotechnology. These systems could lead to customizable molecular transport systems, programmable circuits, and the catalysis of biochemical reactions.
Committee
Carlos Castro (Advisor)
Jonathan Song (Committee Member)
Pages
78 p.
Subject Headings
Mechanical Engineering
Keywords
DNA Origami
;
DNA Nanotechnology
;
Nanostructures
;
Polymerization
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Citations
Serrano Paladines, A. (2021).
Dynamic DNA Origami Assemblies for Signal Transmission
[Master's thesis, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1610037074511565
APA Style (7th edition)
Serrano Paladines, Andres.
Dynamic DNA Origami Assemblies for Signal Transmission.
2021. Ohio State University, Master's thesis.
OhioLINK Electronic Theses and Dissertations Center
, http://rave.ohiolink.edu/etdc/view?acc_num=osu1610037074511565.
MLA Style (8th edition)
Serrano Paladines, Andres. "Dynamic DNA Origami Assemblies for Signal Transmission." Master's thesis, Ohio State University, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=osu1610037074511565
Chicago Manual of Style (17th edition)
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Document number:
osu1610037074511565
Copyright Info
© 2021, all rights reserved.
This open access ETD is published by The Ohio State University and OhioLINK.