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Contribution of organic cation-type transporters to chemotherapy-induced toxicities

Huang, Kevin M
http://rave.ohiolink.edu/etdc/view?acc_num=osu1606768331375801

Abstract Details

2020, Doctor of Philosophy, Ohio State University, Pharmaceutical Sciences.
Membrane transporters are integral proteins contributing to the cellular integrity of all tissue and cell types. The solute carrier superfamily represents the second largest family of membrane proteins, encoding for over 400 transport proteins that collectively, play a pivotal role in cellular homeostasis, including the transport of essential nutrients or ions and the removal of toxic by-products. Moreover, membrane transporters are major contributors to the pharmacokinetics of therapeutic drugs, and the tissue specific expression of uptake transporters can serve as initiating mechanisms that govern a drug’s pharmacodynamic properties (e.g., efficacy and toxicity). Here, we demonstrate that the sub-family of organic cation transporters are critical mediators initiating the debilitating toxicity profiles of chemotherapeutic agents, and that the targeting of these transporters can be exploited clinically to afford protection against injury in healthy tissues without compromising therapeutic benefits.
Alex Sparreboom, PhD (Advisor)
Shuiying Hu, PhD (Advisor)
Cynthia Carnes, PharmD; PhD (Committee Member)
Rajgopal Govindarajan, PhD (Committee Member)
Maryam Lustberg, MD (Committee Member)
Lara Sucheston-Campbell, PhD (Committee Member)
170 p.
Pharmacology
SLC22; transporters; pharmacokinetics; chemotherapy; drug-induced toxicity; oxaliplatin; peripheral neuropathy; doxorubicin; cardiotoxicity; tyrosine kinase inhibitors

Recommended Citations

Citations

  • Huang, K. M. (2020). Contribution of organic cation-type transporters to chemotherapy-induced toxicities [Doctoral dissertation, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1606768331375801

    APA Style (7th edition)

  • Huang, Kevin. Contribution of organic cation-type transporters to chemotherapy-induced toxicities. 2020. Ohio State University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1606768331375801.

    MLA Style (8th edition)

  • Huang, Kevin. "Contribution of organic cation-type transporters to chemotherapy-induced toxicities." Doctoral dissertation, Ohio State University, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=osu1606768331375801

    Chicago Manual of Style (17th edition)

osu1606768331375801
254
© 2020, some rights reserved.Creative Commons License Contribution of organic cation-type transporters to chemotherapy-induced toxicities by Kevin M Huang is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. Based on a work at etd.ohiolink.edu.
This open access ETD is published by The Ohio State University and OhioLINK.
Release 3.2.12