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Biocompatible Electrospun Vehicles To Enhance the Effectiveness Of Anti-Fertility Strategies And Their Biomimetic Properties As Blood Vessel Scaffolds

Chaparro, Francisco Javier
http://orcid.org/0000-0002-7472-9211
http://rave.ohiolink.edu/etdc/view?acc_num=osu1514986344784852

Abstract Details

2018, Doctor of Philosophy, Ohio State University, Materials Science and Engineering.
Electrospun fibers have been extensively studied for drug delivery applications. While fibers made through electrospinning can release a desired drug by engineering various properties, drug loading is typically not sufficient to enable long term release. We explored the use of electrospinning to create polycaprolactone (PCL) capsules sintered to full density allowing encapsulation of both a drug and carriers mainly consisting of hydrophobic or hydrophilic oils, `HPO’ and `HPI’, respectively. The use of HPO demonstrated undetectable water absorption and release of our model drug. In contrast, having HPI as a carrier allowed water uptake into the PCL capsules and was controlled according to the degree of hydrophilicity imparted by these oils. Mechanical properties of as-spun PCL demonstrated to be significantly different from the sintered specimens. PCL samples fully sintered at 100C under vacuum nonetheless demonstrated memory effects as mechanical failure exhibited features of the as-spun microstructure. This memory behavior was lost when samples treated at 150C were analyzed under tensile strength. After 224 days of in vitro and in vivo exposure the microstructure revealed fiber-based yet dense morphology attributed to the memory effects even after sintering at 100C. The use of non-sintered specimens in cylindrical form proved to be effective as a biomimetic scaffold of natural porcine coronary arteries showing similar failure behavior. Although PCL capsules were strong enough to resist compressive force in small animal models, this was not sufficient to study release on large animals. A weak implant can collapse, resulting in an undesired burst release. The incorporation of polyethylene terephthalate (PET) into PCL electrospun fibers in different ratios to then fully densify the capsule through sintering was studied. These blended fibers demonstrated to be mechanically stronger than PCL alone at any studied ratio. Water absorption was able to be controlled by the use of HPO and HPI. Zero order release was observed for all PCL:PET ratios when HPI was used as the carrier. The incorporation of a soluble organic salt into PCL:PET at different salt ratios allowed control of pore size and drug delivery. While typical porogen techniques are able to create microscale porosity, the use of soluble organic salt allowed us to obtain nanoscale porosity after leaching. Interestingly, mechanical properties of these PCL:PET:salt blends at a ratio of 80:10:10 and after heat treatment demonstrated to be significantly higher than specimens without the salt. This study provides design guidance for using electrospinning as a forming technique to create, not only for long term drug delivery capsules, but for other applications that require better mechanical or physical properties that can implement the use of PCL:PET, incorporation of soluble salts and proper use of polymeric electrospun blends.
John Lannutti (Advisor)
Marco da Silva Coutinho (Other)
Heather Powell (Committee Member)
Jianjun Guan (Committee Member)
271 p.
Biomechanics; Biomedical Research; Chemical Engineering; Design; Engineering; Materials Science; Medicine; Nanoscience; Nanotechnology; Organic Chemistry; Plastics; Polymer Chemistry; Polymers
Electrospinning, Drug Delivery, Fiber-memory, Hydrophilic oil, Hydrophobic oil, Silicone oil, Polycaprolactone, Polyethylene terephthalate, Polymers blend, Soluble salt, Porogen, Nanoscale Porosity, Suture Retention Strength, Long Term Drug Delivery

Recommended Citations

Citations

  • Chaparro, F. J. (2018). Biocompatible Electrospun Vehicles To Enhance the Effectiveness Of Anti-Fertility Strategies And Their Biomimetic Properties As Blood Vessel Scaffolds [Doctoral dissertation, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1514986344784852

    APA Style (7th edition)

  • Chaparro, Francisco. Biocompatible Electrospun Vehicles To Enhance the Effectiveness Of Anti-Fertility Strategies And Their Biomimetic Properties As Blood Vessel Scaffolds. 2018. Ohio State University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1514986344784852.

    MLA Style (8th edition)

  • Chaparro, Francisco. "Biocompatible Electrospun Vehicles To Enhance the Effectiveness Of Anti-Fertility Strategies And Their Biomimetic Properties As Blood Vessel Scaffolds." Doctoral dissertation, Ohio State University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=osu1514986344784852

    Chicago Manual of Style (17th edition)

osu1514986344784852
281
© 2018, some rights reserved.Creative Commons License Biocompatible Electrospun Vehicles To Enhance the Effectiveness Of Anti-Fertility Strategies And Their Biomimetic Properties As Blood Vessel Scaffolds by Francisco Javier Chaparro is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. Based on a work at etd.ohiolink.edu.
This open access ETD is published by The Ohio State University and OhioLINK.