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Ayat Aldoori Thesis 8_14.14 PDF.pdf (4.02 MB)

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Elucidation of signaling mediators between adipose and neural tissue

Aldoori, Ayat Dhia
http://rave.ohiolink.edu/etdc/view?acc_num=osu1407845819

Abstract Details

2014, Master of Science, Ohio State University, Human Ecology: Human Nutrition.
Obesity and major mood disorders (MMD), namely bipolar disorder and major depressive disorder, have drastically increased in recent years in the United States adolescent population. Evidence indicates higher levels of circulating pro-inflammatory cytokines in both obesity and mood disorders. The effect of adipokines released by adipose tissue on the central nervous system (CNS) and inflammation in the progression of mood disorders remains understudied. In our study, we aimed to elucidate mediators between adipose and neural tissue that may link progression of mood disorders and metabolic imbalance. We hypothesized that adipose tissue can produce and secrete signaling molecules such as neuroadipokines or inflammatory cytokines that influence CNS function. We investigated 1) production and secretion of glia maturation factor ß (GMFß) in WT and Aldh1a1-/- adipocytes and 2) inflammatory and anti-inflammatory factors in mood disorder patients’ serum and their cumulative inflammatory impact on adipocytes measured by NF-kB, a master transcriptional regulator of inflammation. We found that GMFß is produced and secreted by adipocytes and its expression depends on aldehyde dehydrogenase 1A1. Thus, GMFß is a neuroadipokine that can function in adipose as well as neural tissue. In addition, we found increasing variability of NF-kB and its target cytokines if severity of MMD in patients increases. These data suggest that both suppression and increases in inflammation may influence MMD progression that warrants studies in specific MMD populations.
Ouliana Ziouzenkova, Dr. (Advisor)
Barbara Gracious, Dr. (Committee Member)
Earl Harrison, Dr. (Committee Member)
47 p.
Nutrition
glia maturation factor beta, aldehyde dehydrogenase 1A1, adipokines, mood disorders, nuclear factor kappa beta, neuroadipokines, inflammatory cytokines

Recommended Citations

Citations

  • Aldoori, A. D. (2014). Elucidation of signaling mediators between adipose and neural tissue [Master's thesis, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1407845819

    APA Style (7th edition)

  • Aldoori, Ayat. Elucidation of signaling mediators between adipose and neural tissue . 2014. Ohio State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1407845819.

    MLA Style (8th edition)

  • Aldoori, Ayat. "Elucidation of signaling mediators between adipose and neural tissue ." Master's thesis, Ohio State University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=osu1407845819

    Chicago Manual of Style (17th edition)

osu1407845819
589
© 2014, all rights reserved.
This open access ETD is published by The Ohio State University and OhioLINK.