Skip to Main Content
 

Global Search Box

 
 
 
 

Files

File List


osu1353086436.pdf (1022.89 KB)

ETD Abstract Container

Abstract Header

Pharmacological Modulation of Functional Connectivity in Neuropsychological Disorders

Narayanan, Ananth
http://rave.ohiolink.edu/etdc/view?acc_num=osu1353086436

Abstract Details

2012, Doctor of Philosophy, Ohio State University, Integrated Biomedical Science Graduate Program.
Autism Study: A decrease in interaction between brain regions is observed in individuals with autism spectrum disorder (ASD), which is believed to be related to restricted neural network access in ASD. Propranolol, a beta-adrenergic antagonist, has revealed benefit during performance of tasks involving flexibility of access to networks, a benefit also seen in ASD. Our goal was to determine the effect of propranolol on functional connectivity in ASD during a verbal decision making task as compared to nadolol, thereby accounting for the potential spurious fMRI effects due to peripheral hemodynamic effects of propranolol. Ten ASD subjects underwent fMRI scans after administration of placebo, propranolol or nadolol, while performing a phonological decision making task. Comparison of functional connectivity between pre-defined ROI-pairs revealed a significant increase with propranolol compared to nadolol, suggesting a potential imaging marker for the cognitive effects of propranolol in ASD. Cocaine Withdrawal Study: Recent research revealed decreased access to semantic and associative networks in acute cocaine withdrawal. In autism, such behavioral outcomes are associated with decreased functional connectivity using functional magnetic resonance imaging. Therefore, we wished to determine whether connectivity is also decreased in acute cocaine withdrawal. Eight subjects in acute cocaine withdrawal were compared to controls for connectivity in language areas while performing a word categorization task. Acute withdrawal subjects had significantly less overall connectivity during semantic categorization and a trend towards less connectivity during phonological categorization. This is of interest due to recent research revealing pharmacological effects on connectivity in autism.
David Beversdorf, MD (Advisor)
Petra Schmalbrock, PhD (Advisor)
Doug Scharre, MD (Committee Member)
Michael Knopp, PhD (Committee Member)
Virginia Sanders, PhD (Committee Member)
136 p.
Neurosciences
autism; cocaine withdrawal; fMRI; functional connectivity; functional MRI

Recommended Citations

Citations

  • Narayanan, A. (2012). Pharmacological Modulation of Functional Connectivity in Neuropsychological Disorders [Doctoral dissertation, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1353086436

    APA Style (7th edition)

  • Narayanan, Ananth. Pharmacological Modulation of Functional Connectivity in Neuropsychological Disorders. 2012. Ohio State University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1353086436.

    MLA Style (8th edition)

  • Narayanan, Ananth. "Pharmacological Modulation of Functional Connectivity in Neuropsychological Disorders." Doctoral dissertation, Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1353086436

    Chicago Manual of Style (17th edition)

osu1353086436
725
© 2012, all rights reserved.
This open access ETD is published by The Ohio State University and OhioLINK.