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The Use of Radiographs, Dual-energy X-ray Absorptiometry, Quantitative Computed Tomography and Micro-computed Tomography to Determine Local Cancellous Bone Quality in the Canine Proximal Femur

Townsend, Katy Louise
http://rave.ohiolink.edu/etdc/view?acc_num=osu1336769521

Abstract Details

2012, Master of Science, Ohio State University, Veterinary Clinical Sciences.
Proximal femoral bone quality and quantity are two important variables to provide long-term stability in cementless total hip arthroplasty (THA). The goal of this study is to determine the feasibility of using non-invasive imaging data to predict the quality and quantity of cancellous bone in the canine proximal femur and directly compare this with bone microstructure and mechanical analysis. Twelve cadaveric canine femora were used. Radiographs were taken, along with DEXA scans and quantitative CT. Bone Mineral Content (BMC) and Bone Mineral Density (BMD) were measured from DEXA scans and CT, and radiographs were scored. Cores of cancellous bone were harvested from the proximal femur. High-resolution micro computed tomography (uCT) was performed to assess bone microstructure (fractional bone volume BV/TV, polar moment of inertia). Direct mechanical testing of the bone core was performed to assess bone strength (break load, stiffness, energy at break). Pearson correlation was used to compare the biomechanical parameters with the imaging modalities. uCT values (BV/TV and AMI) had the best predictor of mechanical properties of cancellous bone in the proximal femur, while clinical imaging modalities such as radiographs, DEXA BMD and BMC and qCT had only mild correlation with predicting bone strength. uCT has the best predictor of bone strength, suggesting that bone architecture plays a significant role in determining bone strength. CT, DEXA and radiographs all showed only mild correlation of bone strength, indicating that clinical parameters are not useful in predicting proximal femoral bone strength.
Matthew Allen (Advisor)
Richard Hart (Committee Member)
Valerie Samii (Committee Member)
Jonathan Dyce (Committee Member)
61 p.
Veterinary Services
Dog; bone quality; total hip replacement; mechanical testing; imaging.

Recommended Citations

Citations

  • Townsend, K. L. (2012). The Use of Radiographs, Dual-energy X-ray Absorptiometry, Quantitative Computed Tomography and Micro-computed Tomography to Determine Local Cancellous Bone Quality in the Canine Proximal Femur [Master's thesis, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1336769521

    APA Style (7th edition)

  • Townsend, Katy. The Use of Radiographs, Dual-energy X-ray Absorptiometry, Quantitative Computed Tomography and Micro-computed Tomography to Determine Local Cancellous Bone Quality in the Canine Proximal Femur. 2012. Ohio State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1336769521.

    MLA Style (8th edition)

  • Townsend, Katy. "The Use of Radiographs, Dual-energy X-ray Absorptiometry, Quantitative Computed Tomography and Micro-computed Tomography to Determine Local Cancellous Bone Quality in the Canine Proximal Femur." Master's thesis, Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1336769521

    Chicago Manual of Style (17th edition)

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© 2012, all rights reserved.
This open access ETD is published by The Ohio State University and OhioLINK.