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Cognitive Outcomes Following Arterial Ischemic Stroke in Children

Hajek, Christine A.
http://rave.ohiolink.edu/etdc/view?acc_num=osu1332881238

Abstract Details

2012, Doctor of Philosophy, Ohio State University, Psychology.
Purpose: To determine whether children with arterial ischemic stroke (AIS) display deficits in cognitive functioning and explore factors that may account for individual variability in cognitive outcomes following AIS. Participants and Methods: Participants included 36 children with AIS, which occurred from the perinatal period to childhood but at least 1 year prior to assessment. A comparison group of 15 children with asthma were included to control for acute medical illness requiring hospital admission. Participants ranged from 6 to 15 years of age at the time of the study. Children completed measures of general cognitive ability, attention and executive functions, and processing speed. Children also were assessed using the Pediatric Stroke Outcome Measure (PSOM), a standardized assessment of neurological function. Children in the AIS group also completed an MRI, which was used to determine stroke location and measure lesion volume. Results: Mean cognitive scores fell within the average range for both groups. Compared to children with asthma, children with AIS performed significantly worse on a measure of inhibitory control. Group differences for the remaining cognitive measures were in the same direction but did not reach statistical significance. Children with AIS performed significantly lower than normative populations on several cognitive measures. The PSOM total severity score was significantly negatively correlated with general cognitive ability and processing speed. Stroke volume was significantly negatively correlated with verbal skills and general cognitive ability. Results suggest that greater stroke severity was associated with lower cognitive functioning. Socioeconomic status (SES) was also related to verbal functioning, general cognitive ability, inhibitory control, and processing speed. Stroke location, lesion laterality, age at stroke, and sex were not significantly related to cognitive outcome. Regression analyses indicated that after controlling for SES, greater stroke severity accounted for significant variance in general cognitive ability, verbal skills, and processing speed. Conclusions: Results suggest that following AIS, children performed in the low end of the average range on several cognitive measures. In the AIS group, overall neurological status, stroke severity, and SES were significantly related to general cognitive ability and verbal skills, as well as processing speed. After controlling for SES, stroke severity accounted for significant variance in cognitive functioning.
Keith Yeates, PhD (Advisor)
Steven Beck, PhD (Committee Member)
Michael Vasey, PhD (Committee Member)
176 p.
Clinical Psychology
Pediatric Stroke; Cognitive Outcomes; Pediatric Neuropsychology

Recommended Citations

Citations

  • Hajek, C. A. (2012). Cognitive Outcomes Following Arterial Ischemic Stroke in Children [Doctoral dissertation, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1332881238

    APA Style (7th edition)

  • Hajek, Christine. Cognitive Outcomes Following Arterial Ischemic Stroke in Children. 2012. Ohio State University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1332881238.

    MLA Style (8th edition)

  • Hajek, Christine. "Cognitive Outcomes Following Arterial Ischemic Stroke in Children." Doctoral dissertation, Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1332881238

    Chicago Manual of Style (17th edition)

osu1332881238
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© 2012, all rights reserved.
This open access ETD is published by The Ohio State University and OhioLINK.