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Interleukin 15 and transplantation biology: the interface of innate and adaptive immunity

Blaser, Bradley W
http://rave.ohiolink.edu/etdc/view?acc_num=osu1145978587

Abstract Details

2006, Doctor of Philosophy, Ohio State University, Medical Science.
Years of clinical and experimental evidence have shown that both the antigen-nonspecific innate immune system and the antigen-specific adaptive immune system can effectively eliminate malignant cells that remain after front-line therapy for cancer. Because the immune response to any given stimulus requires the coordinated activity of a large number of diverse cell types, elaborate communication networks have evolved that utilize direct cell-cell interactions as well as soluble growth factors, or cytokines, that can potentially travel great distances in the body. Knowledge of the mechanisms and effects of these cell-cell and cell-cytokine-cell interactions is of paramount importance as physicians and scientists advance the frontiers of cancer immunotherapy. Presented here is a series of studies that define roles for the cytokine interleukin 15 (IL-15) in acute graft versus host disease (GVHD) and graft rejection. Mediated by both the innate and adaptive immune systems, graft rejection and acute GVHD are the most common life threatening side effects of allogeneic bone marrow transplantation (BMT), a promising immunotherapeutic approach for aggressive and otherwise incurable hematopoietic malignancies. Also presented are studies evaluating a novel therapeutic antibody designed to interrupt the cell-cell signals that serve to prevent tumor cell lysis by natural killer (NK) cells, a critical part of the innate immune system. Together, these data unravel a small portion of the complex interactions between immune effector cells and malignant cells and provide justification for future basic and clinical immunotherapeutic studies.
Michael Caligiuri (Advisor)
168 p.
IL-15; bone marrow transplantation; graft versus host disease; T cell; NK cell

Recommended Citations

Citations

  • Blaser, B. W. (2006). Interleukin 15 and transplantation biology: the interface of innate and adaptive immunity [Doctoral dissertation, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1145978587

    APA Style (7th edition)

  • Blaser, Bradley. Interleukin 15 and transplantation biology: the interface of innate and adaptive immunity. 2006. Ohio State University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1145978587.

    MLA Style (8th edition)

  • Blaser, Bradley. "Interleukin 15 and transplantation biology: the interface of innate and adaptive immunity." Doctoral dissertation, Ohio State University, 2006. http://rave.ohiolink.edu/etdc/view?acc_num=osu1145978587

    Chicago Manual of Style (17th edition)

osu1145978587
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© 2006, all rights reserved.
This open access ETD is published by The Ohio State University and OhioLINK.