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Design, Synthesis, and Evaluation of Manganese(I) Photoinduced CO-releasing Molecules and Water-Soluble Lanthanide Cages

Pordel, Shabnam
http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1660674630082014

Abstract Details

2022, Doctor of Philosophy (PhD), Ohio University, Chemistry and Biochemistry (Arts and Sciences).
Carbon monoxide (CO) is a toxic gas that has been known as the “silent killer” for decades. At high concentrations, CO reacts with hemoglobin, impairing its ability to transfer oxygen throughout the body. At low concentrations, however, CO has anti-cancer and anti-inflammatory effects. CO has also been shown to increase the sensitivity of certain types of cancer cells to the reactive oxygen species (ROS) produced by chemotherapeutics, thereby reducing drug resistance. One way to deliver CO in a controlled and safe manner is through the use of photoCORMs, or photoactivated CO releasing molecules. Transition metal-based photoCORMs are a class of molecules that release CO by breaking the M-CO bond upon exposure to light. In Chapters 2 and 3, my research study the effect of ligand set variation (both electronically and sterically) around the Mn(I) metal center on the photophysical and photochemical properties, as well as the assignment of photochemical intermediate formation during visible light irradiation. In Chapter 4, we designed a system that combined photo-activated CO delivery and singlet oxygen (1O2). The photophysical and photochemical properties of two Mn(I)-based photoCORMs sensitized with a luminescent BODIPY, as well as their ability to generate singlet oxygen during visible light irradiation were investigated.iv In Chapter 5, my focus was on water-soluble 3D supramolecular coordination cages (SCCs). The internal cavity incorporated in these structures allows them to encapsulate various guest molecules. Water-soluble Ln(III)-based SCCs are scarce, and the arrangement of water molecules inside the cavity, as well as the recognition properties of the latter, are mostly unknown. The study of such interactions would be of interest to the growing field of SCCs. To this end, we designed and synthesized a water-soluble Eu(III)-based supramolecular coordination cage with the general formula of Eu2L3 and a triplestranded helicate structure. The guest binding properties of the Eu2L3 cage were studied with smaller mono- and di-cationic organic guests through 1H NMR titration in D2O.
Eric Masson (Advisor)
Chemistry
photoCORM; Manganese; BODIPY; Singlet oxygen; Lanthanide Cages

Recommended Citations

Citations

  • Pordel, S. (2022). Design, Synthesis, and Evaluation of Manganese(I) Photoinduced CO-releasing Molecules and Water-Soluble Lanthanide Cages [Doctoral dissertation, Ohio University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1660674630082014

    APA Style (7th edition)

  • Pordel, Shabnam. Design, Synthesis, and Evaluation of Manganese(I) Photoinduced CO-releasing Molecules and Water-Soluble Lanthanide Cages. 2022. Ohio University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1660674630082014.

    MLA Style (8th edition)

  • Pordel, Shabnam. "Design, Synthesis, and Evaluation of Manganese(I) Photoinduced CO-releasing Molecules and Water-Soluble Lanthanide Cages." Doctoral dissertation, Ohio University, 2022. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1660674630082014

    Chicago Manual of Style (17th edition)

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