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Mass Spectrometry of Carbohydrates by Experimental and Theoretical Methods

Rabus, Jordan
http://orcid.org/0000-0002-3425-0062
http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1628688928273698

Abstract Details

2021, Doctor of Philosophy (PhD), Ohio University, Chemistry and Biochemistry (Arts and Sciences).
This dissertation is focused on the study of the fragmentation chemistry of carbohydrates by mass spectrometry and computational methods. By investigating the behavior of model systems, we hypothesize that a general model for carbohydrate fragmentation can be found. The model systems studied are sodiated cellobiose and gentiobiose (Chapter 2), deprotonated lactose (Chapter 3), and β-cyclodextrin (Chapter 4), each representing a different aspect of carbohydrate fragmentation. Experimental techniques, including tandem mass spectrometry, stable isotopic labeling, and infrared multiphoton dissociation were employed. Throughout, we also utilize computational modeling to add a dimension of clarity to the experimental results and provide values usable in subsequent predictive efforts.
Benjamin Bythell (Advisor)
Martin Kordesch (Committee Member)
Peter Harrington (Committee Member)
Jixin Chen (Committee Member)
210 p.
Chemistry; Molecular Chemistry
Mass spectrometry; computational chemistry; carbohydrates; glycans

Recommended Citations

Citations

  • Rabus, J. (2021). Mass Spectrometry of Carbohydrates by Experimental and Theoretical Methods [Doctoral dissertation, Ohio University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1628688928273698

    APA Style (7th edition)

  • Rabus, Jordan. Mass Spectrometry of Carbohydrates by Experimental and Theoretical Methods. 2021. Ohio University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1628688928273698.

    MLA Style (8th edition)

  • Rabus, Jordan. "Mass Spectrometry of Carbohydrates by Experimental and Theoretical Methods." Doctoral dissertation, Ohio University, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1628688928273698

    Chicago Manual of Style (17th edition)

ohiou1628688928273698
562
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This open access ETD is published by Ohio University and OhioLINK.