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Guan, Shanshan Accepted Dissertation 3-25-21 Sp 21.pdf (11.14 MB)
ETD Abstract Container
Abstract Header
Mass Spectrometry-based Fragmentation Chemistry of Small Biological Compounds
Author Info
Guan, Shanshan
Permalink:
http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1616802495967559
Abstract Details
Year and Degree
2021, Doctor of Philosophy (PhD), Ohio University, Chemistry and Biochemistry (Arts and Sciences).
Abstract
In this dissertation, the gas-phase fragmentation chemistries of different biological compounds were characterized. We employed the tandem mass spectra of the analytes and detailed density functional theory (DFT) reaction pathway calculations to rationalize the gas-phase fragmentation mechanisms. We investigated the fragmentation characteristics of doubly protonated small peptides of different lengths and compositions (Chapter 2). We studied the fragmentation mechanism of deprotonated peptide that can offer complementary information for the most utilized protonated peptide analysis (Chapter 3). The fragmentation chemistries of different peptidoglycans which were characterized in Chapter 4. In addition, we have developed a method for facile differentiation of acidic, isomeric metabolites by attaching high proton affinity, piperidine-based chemical tags to carboxylic acid groups followed by LC-MS/MS analysis (Chapter 5).
Committee
Benjamin Bythell (Advisor)
Pages
290 p.
Subject Headings
Chemistry
Keywords
Mass Spectrometry
;
Fragmentation
;
Chemistry
;
Compounds
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Citations
Guan, S. (2021).
Mass Spectrometry-based Fragmentation Chemistry of Small Biological Compounds
[Doctoral dissertation, Ohio University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1616802495967559
APA Style (7th edition)
Guan, Shanshan.
Mass Spectrometry-based Fragmentation Chemistry of Small Biological Compounds.
2021. Ohio University, Doctoral dissertation.
OhioLINK Electronic Theses and Dissertations Center
, http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1616802495967559.
MLA Style (8th edition)
Guan, Shanshan. "Mass Spectrometry-based Fragmentation Chemistry of Small Biological Compounds." Doctoral dissertation, Ohio University, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1616802495967559
Chicago Manual of Style (17th edition)
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Document number:
ohiou1616802495967559
Download Count:
93
Copyright Info
© 2021, all rights reserved.
This open access ETD is published by Ohio University and OhioLINK.