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In silico and in vitro Toxicity Study of Two Novel Compounds that Exhibit Promising Therapeutic Potential

Steen, Kayla M.
http://orcid.org/0000-0003-3458-2072
http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1564760758005406

Abstract Details

2019, Master of Science (MS), Ohio University, Biomedical Engineering (Engineering and Technology).
Drug development is an ever-increasingly prominent field in the scientific community. A crucial step in the drug development process involves examining the toxicity of potential therapeutic compounds. A plethora of organic compounds have been synthesized through an ongoing drug discovery program at Ohio University. Two of these compounds have demonstrated significant promise in several models of disease. In the present study, the potential toxicity of these two compounds was evaluated via in silico and in vitro techniques.
Douglas Goetz, Ph. D. (Advisor)
Monica Burdick, Ph. D. (Committee Member)
Sumit Sharma, Ph. D. (Committee Member)
Robert Colvin, Ph. D. (Committee Member)
78 p.
Biomedical Engineering; Biomedical Research
Drug; Drug Development; Therapeutic; Toxicity; Potential Toxicity; Compounds; Novel Compounds; in silico; in vitro; THP-1; HUVEC; IDO; NAFLD

Recommended Citations

Citations

  • Steen, K. M. (2019). In silico and in vitro Toxicity Study of Two Novel Compounds that Exhibit Promising Therapeutic Potential [Master's thesis, Ohio University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1564760758005406

    APA Style (7th edition)

  • Steen, Kayla. In silico and in vitro Toxicity Study of Two Novel Compounds that Exhibit Promising Therapeutic Potential. 2019. Ohio University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1564760758005406.

    MLA Style (8th edition)

  • Steen, Kayla. "In silico and in vitro Toxicity Study of Two Novel Compounds that Exhibit Promising Therapeutic Potential." Master's thesis, Ohio University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1564760758005406

    Chicago Manual of Style (17th edition)

ohiou1564760758005406
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This open access ETD is published by Ohio University and OhioLINK.
Release 3.2.12