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The Effects of Growth Hormone Action on the Mouse Intestine

Young, Jonathan A.
http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1534865806561942

Abstract Details

2018, Doctor of Philosophy (PhD), Ohio University, Molecular and Cellular Biology (Arts and Sciences).
Growth Hormone (GH) is well known to have prominent anabolic effects on bone, muscle and fat, but its effects on the gastrointestinal tract are less well studied. The fact that recombinant GH therapy has been used to treat intestinal diseases such as short bowel syndrome and inflammatory bowel disease indicates that GH can exert effects in the intestines. However, little is known about the basic biological effects of GH on this organ. The focus of this study was to examine the effects of GH in the absence of intestinal disease using genetically altered mice. Mice with systemic alterations in GH activity displayed morphological and metabolic changes that correlated with levels of GH action. In a mouse model with the GH receptor (GHR) gene disrupted in intestinal epithelial cells, there were sex specific changes in intestinal length, glucose metabolism, barrier function, and fat absorption, but no apparent changes in mucosal morphology. In other experimental models, genetically engineered mice with chronically increased GH showed increases in collagen protein content with no detectable change in collagen gene expression. Mice with chronically decreased GH showed a decrease in collagen protein content with no significant change in collagen gene expression. An increase in collagen gene expression was observed in wild-type mice after one month of daily injections of GH. These findings establish some effects of GH action on the intestines and encourage further examination of intestinal GH induced signaling on overall animal physiology.
John Kopchick, PhD (Advisor)
Darlene Berryman, PhD (Committee Member)
Mark Berryman, PhD (Committee Member)
Fabian Benencia, PhD (Committee Member)
116 p.
Biology; Cellular Biology; Endocrinology; Genetics; Molecular Biology
growth hormone; intestine; collagen; bGH; GHRKO; GHA; GH; growth hormone receptor

Recommended Citations

Citations

  • Young, J. A. (2018). The Effects of Growth Hormone Action on the Mouse Intestine [Doctoral dissertation, Ohio University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1534865806561942

    APA Style (7th edition)

  • Young, Jonathan. The Effects of Growth Hormone Action on the Mouse Intestine. 2018. Ohio University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1534865806561942.

    MLA Style (8th edition)

  • Young, Jonathan. "The Effects of Growth Hormone Action on the Mouse Intestine." Doctoral dissertation, Ohio University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1534865806561942

    Chicago Manual of Style (17th edition)

ohiou1534865806561942
146
© 2018, all rights reserved.
This open access ETD is published by Ohio University and OhioLINK.
Release 3.2.12