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A Natural Product and High-Throughput Screening Synthetic Approach Towards the Discovery of Antileishmanial Agents

Scaduto, Ryan
http://rave.ohiolink.edu/etdc/view?acc_num=oduhonors1620081955401195

Abstract Details

2021, Honors Theses, Ohio Dominican University, Honors Theses.
Leishmaniasis is a neglected tropical disease which affects millions of people every year across 6 continents. Current antileishmanial drugs have become less effective due to resistance, have a high toxicity, and are too expensive for many lower socioeconomic countries. New drug candidates can be explored and synthesized by natural drug synthesis and high throughput screening (HTS). This paper aimed to explore both methods in search of novel antileishmanial compounds. For the natural product approach, the ABC ring of berberine will be optimized to improve its antileishmanial properties. For the HTS approach, a piperazine based small molecule has been synthesized and will be evaluated for its antileishmanial properties.
Janet Antwi (Advisor)
Blake Mathys (Other)
Arlene Ramkissoon (Committee Member)
John Marazita (Committee Chair)
21 p.
Biochemistry; Biology; Biomedical Research; Chemistry; Epidemiology; Organic Chemistry; Parasitology; Pharmaceuticals; Pharmacology
Leishmaniasis; Neglected Tropical Disease; Natural Drug Discovery; High throughput screening; structure optimization; derivatives; semi synthesis; total synthesis; organic chemistry

Recommended Citations

Citations

  • Scaduto, R. (2021). A Natural Product and High-Throughput Screening Synthetic Approach Towards the Discovery of Antileishmanial Agents [Electronic thesis or dissertation, Ohio Dominican University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=oduhonors1620081955401195

    APA Style (7th edition)

  • Scaduto, Ryan. A Natural Product and High-Throughput Screening Synthetic Approach Towards the Discovery of Antileishmanial Agents. 2021. Ohio Dominican University, Electronic thesis or dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=oduhonors1620081955401195.

    MLA Style (8th edition)

  • Scaduto, Ryan. "A Natural Product and High-Throughput Screening Synthetic Approach Towards the Discovery of Antileishmanial Agents." Electronic thesis or dissertation, Ohio Dominican University, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=oduhonors1620081955401195

    Chicago Manual of Style (17th edition)

oduhonors1620081955401195
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This open access ETD is published by Ohio Dominican University Honors Theses and OhioLINK.