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Development of a Fluorescence-Based Screen for Glutathione-S-Transferase Inhibitors

Gorzitze-Maxey, Adrian Dale
http://rave.ohiolink.edu/etdc/view?acc_num=oduhonors1449612834

Abstract Details

2015, Honors Theses, Ohio Dominican University, Honors Theses.
An experimental project regarding the synthesis of a new molecule and using it in development of a fluorescence-based screen for competitive glutathione-S-transferase (GST) inhibitors. Although an essential, detoxifying enzyme in healthy individuals, GST attacks chemotherapy cytotoxins in cancer patients, limiting the life-saving effects of the treatment. This new fluorescent glutathione molecule and screen for inhibitors provides the search for chemotherapy targeting GST inhibitors with a new and the most efficient technique for screening these inhibitors.
Dinty Musk, Dr. (Advisor)
29 p.
Biochemistry; Chemistry; Organic Chemistry
GST; glutathione-s-transferase; florescence-based screen; fluorescent tag; glutathione; chemotherapy; fluorescent glutathione; biochemistry; chemistry; organic chemistry; prep-scale tlc; unique molecule; GST inhibitors screen; GST inhibitors

Recommended Citations

Citations

  • Gorzitze-Maxey, A. D. (2015). Development of a Fluorescence-Based Screen for Glutathione-S-Transferase Inhibitors [Electronic thesis or dissertation, Ohio Dominican University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=oduhonors1449612834

    APA Style (7th edition)

  • Gorzitze-Maxey, Adrian. Development of a Fluorescence-Based Screen for Glutathione-S-Transferase Inhibitors . 2015. Ohio Dominican University, Electronic thesis or dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=oduhonors1449612834.

    MLA Style (8th edition)

  • Gorzitze-Maxey, Adrian. "Development of a Fluorescence-Based Screen for Glutathione-S-Transferase Inhibitors ." Electronic thesis or dissertation, Ohio Dominican University, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=oduhonors1449612834

    Chicago Manual of Style (17th edition)

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This open access ETD is published by Ohio Dominican University Honors Theses and OhioLINK.
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