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Full text release has been delayed at the author's request until July 17, 2027

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Exploring the Genetic Basis of Local Adaptation

Farleigh, Keaka
http://orcid.org/0000-0002-9195-121X
http://rave.ohiolink.edu/etdc/view?acc_num=miami1721227037249867

Abstract Details

2024, Doctor of Philosophy, Miami University, Biology.
This dissertation is structured into five chapters. Chapter I: I provide a general introduction to my dissertation, primarily introducing the different influences on intraspecific variation and providing a background on local adaptation. Chapter II: I investigate the effects of environmental conditions and demographic history on populations of desert horned lizards (Phrynosoma platyrhinos). I evaluate the demographic history of P. platyrhinos and identify signatures of selection associated with climate, which may be indicative of local adaptation. I then link signatures of selection to genes and functional genomic elements. Chapter III: I explore the influence of environmental heterogeneity on intraspecific variation of the chisel-toothed kangaroo rat (Dipodomys microps). I discover signals of selection associated with both climate and vegetation. I also find evidence that selective pressures likely vary across the species distribution and develop a permutation test to identify populations that possess more putatively adaptive alleles than expected by chance. I also link signals of selection to genes and biological functions that may be related to previously identified morphological differences between populations. Chapter IV: I perform a meta-analysis to understand general patterns of putative local adaptation in terrestrial chordates. I use previously published datasets and analyze them using a common framework to test theoretical predictions regarding the relationship between environmental and demographic factors and signals of selection. I find that signals of selection follow theoretical predictions, and, importantly, find that constant variation is an important driver of signals of selection. Chapter V: I provide conclusions and future directions from my results.
Tereza Jezkova (Advisor)
David Berg (Committee Member)
Donghyung Lee (Committee Member)
Richard Moore (Committee Member)
Susan Hoffmann (Committee Member)
153 p.
Bioinformatics; Biology; Climate Change; Evolution and Development
Local adaptation; climate; genome-environment; single nucleotide polymorphism; SNP; phrynosoma; platyrhinos; dipodomys; microps; tetrapoda; biogeography; RADseq; ddRADseq; reptile; mammal; adaptation; Great Basin; Mojave; climate change; Last Glacial Maximum; climate velocity

Recommended Citations

Citations

  • Farleigh, K. (2024). Exploring the Genetic Basis of Local Adaptation [Doctoral dissertation, Miami University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=miami1721227037249867

    APA Style (7th edition)

  • Farleigh, Keaka. Exploring the Genetic Basis of Local Adaptation. 2024. Miami University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=miami1721227037249867.

    MLA Style (8th edition)

  • Farleigh, Keaka. "Exploring the Genetic Basis of Local Adaptation." Doctoral dissertation, Miami University, 2024. http://rave.ohiolink.edu/etdc/view?acc_num=miami1721227037249867

    Chicago Manual of Style (17th edition)

miami1721227037249867
© 2024, all rights reserved.
This open access ETD is published by Miami University and OhioLINK.