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PPARγ Agonist and Antagonist Regulation of Migratory Adiposity in the Gray Catbird (Dumetella Carolinensis)

Valachovic, Abigail Corrine
http://orcid.org/0000-0003-0916-4530
http://rave.ohiolink.edu/etdc/view?acc_num=miami1650487032399289

Abstract Details

2022, Master of Science, Miami University, Biology.
The Gray Catbird (Dumetella carolinensis) is an excellent model to study migratory physiology because of its life-history. Conceptually, life-history tradeoffs around migration and adipose accumulation are not novel, but questions remain regarding the regulation of life-history transitions. One possible mechanism for adipose changes is PPARγ. This study assesses change in the migratory phenotype associated with photoperiod manipulation and pharmaceutical PPARγ agonist/antagonist drugs. We hypothesize that PPARγ activity is necessary to prepare for migration and is sufficient to induce the migratory phenotype. Catbirds in summer conditions were surgically implanted with osmotic pumps that released a PPARγ agonist drug, while birds in fall conditions were given a PPARγ antagonist drug. Two experiments were done, first in an animal care facility and, second, in aviaries. We found that in the facility-housed catbirds there was no significant change in body weight or composition. However, in the aviary-housed catbirds, there were changes in body weight and composition that challenged our predictions. This suggests that PPARγ may not play as large of a role in fat accumulation and mobilization in these migratory birds as hypothesized.
Paul Schaeffer (Advisor)
Paul Harding (Committee Member)
David Russell (Committee Member)
52 p.
Animal Sciences; Biology; Ecology; Physiology
Migratory, Adipose, Catbird, PPARγ, Accumulation, Mobilization, Rosiglitazone, GW9662

Recommended Citations

Citations

  • Valachovic, A. C. (2022). PPARγ Agonist and Antagonist Regulation of Migratory Adiposity in the Gray Catbird (Dumetella Carolinensis) [Master's thesis, Miami University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=miami1650487032399289

    APA Style (7th edition)

  • Valachovic, Abigail. PPARγ Agonist and Antagonist Regulation of Migratory Adiposity in the Gray Catbird (Dumetella Carolinensis). 2022. Miami University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=miami1650487032399289.

    MLA Style (8th edition)

  • Valachovic, Abigail. "PPARγ Agonist and Antagonist Regulation of Migratory Adiposity in the Gray Catbird (Dumetella Carolinensis)." Master's thesis, Miami University, 2022. http://rave.ohiolink.edu/etdc/view?acc_num=miami1650487032399289

    Chicago Manual of Style (17th edition)

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© 2022, all rights reserved.
This open access ETD is published by Miami University and OhioLINK.
Release 3.2.12