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3D PRINTING TO CONTROL DRUG RELEASE FROM KERATIN HYDROGELS

Brodin, Erik W, V
http://orcid.org/0000-0002-4674-9936
http://rave.ohiolink.edu/etdc/view?acc_num=miami1531836971880273

Abstract Details

2018, Master of Science, Miami University, Chemical, Paper and Biomedical Engineering.
Five to ten percent of bone fractures are classified as critical size defects (CSD), which are fractures that will not fuse without medical intervention. Currently the preferred course of treatment is autografts or allografts however both have high complication rates and require aggressive surgeries. BMP2 is a drug known to promote bone growth when implanted in vivo and is currently used for some orthopedic treatments. However, the amount administered and release rate are critical to its therapeutic success. Keratin hydrogels have been shown to be excellent implant materials, promoting cell proliferation and integration. Direct ink write (DIW) 3D printing allows for hydrogel materials to be 3D printed in customizable shapes using various materials, but printing requires knowledge of the fluid properties of the hydrogel. In this study we show that the printing pressure and speed for printing a hydrogel can be predicted. And we show that DIW printing can be used to tune a drug’s release profile if the diffusivity is low enough.
Jessica Sparks (Advisor)
Justin Saul (Committee Member)
Jason Berberich (Committee Member)
Jens Mueller (Committee Member)
72 p.
Biomedical Engineering
3D Printing, Additive Manufacturing, Hydrogel, Keratin, Drug Release

Recommended Citations

Citations

  • Brodin, V, E. W. (2018). 3D PRINTING TO CONTROL DRUG RELEASE FROM KERATIN HYDROGELS [Master's thesis, Miami University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=miami1531836971880273

    APA Style (7th edition)

  • Brodin, V, Erik. 3D PRINTING TO CONTROL DRUG RELEASE FROM KERATIN HYDROGELS. 2018. Miami University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=miami1531836971880273.

    MLA Style (8th edition)

  • Brodin, V, Erik. "3D PRINTING TO CONTROL DRUG RELEASE FROM KERATIN HYDROGELS." Master's thesis, Miami University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=miami1531836971880273

    Chicago Manual of Style (17th edition)

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This open access ETD is published by Miami University and OhioLINK.