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MULTICOMPONENT REACTIONS OF SALICYLALDEHYDE, CYCLIC KETONES, AND ARYLAMINES THROUGH COOPERATIVE ENAMINE-METAL LEWIS ACID CATALYSIS

Sarkisian, Ryan Gregory
http://rave.ohiolink.edu/etdc/view?acc_num=miami1409236804

Abstract Details

2014, Master of Science, Miami University, Chemistry and Biochemistry.
Multicomponent reactions (MCRs) are the most atom economic, highly selective, and convergent type of reaction. This allows for a reaction to have a wide scope and allows for maximization of the complexity of a product. Catalyzing these MCRs with asymmetric catalysis is a novel way to introduce stereocontrol into highly complex molecules with various functional groups. Asymmetric catalysis is considered the most efficient method for constructing highly functionalized optically active stereopure compounds. There are three pillars of asymmetric catalysis: biocatalysis, transition metal catalysis, and organocatalysis. This research focuses on two of these pillars, transition metal catalysis and organocatalysis, working cooperatively to catalyze this MCR. The focus is to educate or refresh the audience on the basic topics that make up the complexity of the MCRs being catalyzed by cooperative asymmetric catalysis. Ultimately to explore the cooperative catalysts used to synthesize both the racemic and asymmetric three fused ring products (9-((4-methoxyphenyl)amino)-2,3,4,4a,9,9a-hexahydro-1H-xanthen-4a-ol).
Hong Wang (Advisor)
Scott Hartley (Committee Member)
Richard Taylor (Committee Member)
David Tierney (Committee Member)
109 p.
Chemistry
Multicomponent Reactions, Cooperative Catalysis, Asymmetric Catalysis, Transition Metal Catalysis, Organocatalysis, Arylamines, Salicylaldehyde, Cyclic Ketones

Recommended Citations

Citations

  • Sarkisian, R. G. (2014). MULTICOMPONENT REACTIONS OF SALICYLALDEHYDE, CYCLIC KETONES, AND ARYLAMINES THROUGH COOPERATIVE ENAMINE-METAL LEWIS ACID CATALYSIS [Master's thesis, Miami University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=miami1409236804

    APA Style (7th edition)

  • Sarkisian, Ryan . MULTICOMPONENT REACTIONS OF SALICYLALDEHYDE, CYCLIC KETONES, AND ARYLAMINES THROUGH COOPERATIVE ENAMINE-METAL LEWIS ACID CATALYSIS. 2014. Miami University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=miami1409236804.

    MLA Style (8th edition)

  • Sarkisian, Ryan . "MULTICOMPONENT REACTIONS OF SALICYLALDEHYDE, CYCLIC KETONES, AND ARYLAMINES THROUGH COOPERATIVE ENAMINE-METAL LEWIS ACID CATALYSIS." Master's thesis, Miami University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=miami1409236804

    Chicago Manual of Style (17th edition)

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This open access ETD is published by Miami University and OhioLINK.
Release 3.2.12