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Siefert_Master's Thesis.pdf (1.84 MB)

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GLIAL CELL REMODELING DURING TERMINAL NERVE TRUNK FORMATION IN DROSOPHILA MELANOGASTER

Siefert, Matthew Emerson
http://rave.ohiolink.edu/etdc/view?acc_num=miami1386158957

Abstract Details

2013, Master of Science, Miami University, Zoology.
During Drosophila development, remodeling of the larval nervous system is necessary for adult specific behavior. During metamorphosis abdominal peripheral nerves fuse to form a terminal nerve trunk (TNT). We propose that glial cells are required for this fusion to occur. Here, four glial layers that ensheath Drosophila peripheral nerves are analyzed. The inner most layer, wrapping glia, and outermost layer, neural lamella, are not present during TNT formation, while the perineurial and subperineurial glial layers persist. Glial cells increases 3 fold during early pupation and ~75% of these glia are perineurial glia. Induction of perineurial glial cell death via the cell death gene reaper, resulted in abnormal TNT formation, suggesting that perineurial glial cells play a role in the fusion process. The characterization of Drosophila glial layers during development will allow for future functional studies and could lead to a model system used to study gliopathies.
Joyce Fernandes (Advisor)
Lori Isaacson (Committee Member)
Kathleen Killian (Committee Member)
63 p.
Zoology
Glial Cells; Nervous System Remodeling; Drosophila

Recommended Citations

Citations

  • Siefert, M. E. (2013). GLIAL CELL REMODELING DURING TERMINAL NERVE TRUNK FORMATION IN DROSOPHILA MELANOGASTER [Master's thesis, Miami University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=miami1386158957

    APA Style (7th edition)

  • Siefert, Matthew. GLIAL CELL REMODELING DURING TERMINAL NERVE TRUNK FORMATION IN DROSOPHILA MELANOGASTER . 2013. Miami University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=miami1386158957.

    MLA Style (8th edition)

  • Siefert, Matthew. "GLIAL CELL REMODELING DURING TERMINAL NERVE TRUNK FORMATION IN DROSOPHILA MELANOGASTER ." Master's thesis, Miami University, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=miami1386158957

    Chicago Manual of Style (17th edition)

miami1386158957
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© 2013, all rights reserved.
This open access ETD is published by Miami University and OhioLINK.