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ELIZABETH AGBOLUAJE-FINAL THESIS.pdf (3.06 MB)

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Formulating an Essential Oil Extracted from Monodora myristica into a Tablet That Forms In-situ Nanostructured Dispersions.

Agboluaje, Elizabeth Oladoyin
http://rave.ohiolink.edu/etdc/view?acc_num=mco1620408006464643

Abstract Details

2021, Master of Science in Pharmaceutical Science (MSP), University of Toledo, Pharmaceutical Sciences (Industrial Pharmacy).
Self-micro-emulsifying drug delivery systems (SMEDDS) have been proven to have improved drug stability, lower toxicity, and increase bioavailability of insoluble drugs. It is a drug delivery design that can prevent physical and chemical drug degradation. The goal of this study was to develop a solid formulation incorporating a self-micro-emulsifying drug delivery system (SMEDDS) for the oral delivery of Monodora myristica essential oil (MMEO). MMEO was extracted from the blended seeds of Monodora myristica using the hydro-distillation method. MMEO was characterized by evaluating the physicochemical properties to ascertain the quality and purity of the essential oil by comparing with MMEO data in the literature. The design of the experiment was done by using Fusion Pro by S-Matrix (Fusion Pro Software Version 9.9.0 Build690, S-Matrix Corporation (www.smatrix.com)) to compare a combination of MMEO/Tween 80/Transcutol HP and MMEO/ Kolliphor/ Labrasol 12 formulations. MMEO (10.92%) / Tween 80 (48%) /Transcutol HP (41.8%) was predicted to be the best formulation with desirable characteristics such as a mean particle size of 112.7 nm, the zeta potential of +5.10 mv, and a transparent emulsion. The emulsion formed was stable over 90 days without any form of emulsion instability or oil precipitation. The liquid-SMEDDS was adsorbed unto Neusilin US2 to form solid-SMEDDS. The solid-SMEDDS was added to cellulose, lactose, starch, talc, magnesium stearate to directly compress type 1 and type 2 tablets while the solid-SMEDDS was directly compressed to formulate type 3 tablets. Type 3 tablets had the highest drug loading capacity unlike type 1 and type 2 tablets. Also, type 3 had the highest breaking force and longest disintegration time. Using one-way ANOVA, the P-value obtained was below 0.05 for tablet thickness, tablet breaking force, and disintegration tests. Therefore, there was a statistically significant difference between type 1, type 2, and type 3 tablets properties such as tablet thickness (<0.001), tablet breaking force (<0.001), and disintegration time (<0.001). The p-value for the % friability (0.081) was above 0.05. Thus, there is no significant difference in the % weight loss for type 1, type 2, and type 3 tablets. A tablet-loaded SMEDDS formulation is a promising approach to deliver essential oils ( water poorly soluble drugs). Excipients such as cellulose, starch, lactose, talc, magnesium stearate did not improve the physicochemical properties of type 1 and type 2 tablets. Based on data obtained from this study, it may be concluded that type 3 tablet design should be adopted for further studies. Solid-SMEDDS may also be filled into capsule shells and comparative studies can be done with type 3 tablets. In-vivo bioavailability studies can also be done to better evaluate the type-3 tablets. Animal studies to test for the pharmacology properties like; Alzheimer, anticancer, antioxidant, and antimicrobial properties of the formulation will provide information about the utility of MMEO as a therapeutic agent.
Jerry Nesamony, Dr (Committee Chair)
Gabriella Baki, Dr (Committee Member)
Liyanaaratchige Tillekeratne, Dr (Committee Member)
90 p.
Health Sciences; Intellectual Property
Monodora myristica, Essential Oil, Solid-self emulsifying drug delivery system, Design of experiment, Tablets, Direct Compression

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Citations

  • Agboluaje, E. O. (2021). Formulating an Essential Oil Extracted from Monodora myristica into a Tablet That Forms In-situ Nanostructured Dispersions. [Master's thesis, University of Toledo]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=mco1620408006464643

    APA Style (7th edition)

  • Agboluaje, Elizabeth. Formulating an Essential Oil Extracted from Monodora myristica into a Tablet That Forms In-situ Nanostructured Dispersions. 2021. University of Toledo, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=mco1620408006464643.

    MLA Style (8th edition)

  • Agboluaje, Elizabeth. " Formulating an Essential Oil Extracted from Monodora myristica into a Tablet That Forms In-situ Nanostructured Dispersions." Master's thesis, University of Toledo, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=mco1620408006464643

    Chicago Manual of Style (17th edition)

mco1620408006464643
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This open access ETD is published by University of Toledo Health Science Campus and OhioLINK.