Skip to Main Content
 

Global Search Box

 
 
 

ETD Abstract Container

Abstract Header

Synthesis and Characterization of Fe (III) Complexes of 8- Hydroxyquinolines and Their Antimicrobial Activity against Staphylococcus aureus and Multidrug-Resistant Staphylococcus aureus

Alidrees, Amjad Idrees
http://rave.ohiolink.edu/etdc/view?acc_num=kent1745607965941392

Abstract Details

2025, PHD, Kent State University, College of Arts and Sciences / Department of Chemistry and Biochemistry.
The emergence of multidrug-resistant bacteria, particularly Staphylococcus aureus and Acinetobacter baumannii, presents an urgent need for new antimicrobial strategies. This research focuses on the synthesis and characterization of novel Fe(III) complexes formed with structurally distinct 8-hydroxyquinoline derivatives: 4-methyl-8-hydroxyquinoline, 5-nitro-8-hydroxyquinoline (nitroxoline), and 7-chloro-5-nitro-8-hydroxyquinoline. The complexes were characterized by UV-Vis spectroscopy, FT-IR spectroscopy, elemental analysis, LC-MS, and single-crystal X-ray diffraction. Their antibacterial activity was evaluated against methicillin-sensitive and methicillin-resistant Staphylococcus aureus (MSSA, MRSA), vancomycin-intermediate S. aureus (VISA), and A. baumannii. Minimum inhibitory concentration (MIC) assays, colony-forming unit counts, intracellular reactive oxygen species (ROS) assays, resistance development studies, hemolysis assays, and checkerboard synergy tests were performed. Results demonstrated that the Fe(III) complexes significantly enhanced antibacterial activity compared to free ligands, primarily by disrupting bacterial iron homeostasis and inducing ROS production. The findings offer promising insights into developing Fe(III)-based antimicrobial agents to combat antibiotic-resistant bacterial infections.
Songping D Huang (Advisor)
Mietek Jaroniec (Committee Member)
Xiaozhen (Jen) Mou (Committee Member)
Almut Schroeder (Committee Member)
Zhiqiang Wang (Committee Member)
118 p.
Biochemistry; Chemistry; Science Education
Multidrug-resistant; bacteria; research; Acinetobacter baumannii; spectroscopy; antibiotic; infections; Fe(III)

Recommended Citations

Citations

  • Alidrees, A. I. (2025). Synthesis and Characterization of Fe (III) Complexes of 8- Hydroxyquinolines and Their Antimicrobial Activity against Staphylococcus aureus and Multidrug-Resistant Staphylococcus aureus [Doctoral dissertation, Kent State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=kent1745607965941392

    APA Style (7th edition)

  • Alidrees, Amjad. Synthesis and Characterization of Fe (III) Complexes of 8- Hydroxyquinolines and Their Antimicrobial Activity against Staphylococcus aureus and Multidrug-Resistant Staphylococcus aureus . 2025. Kent State University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=kent1745607965941392.

    MLA Style (8th edition)

  • Alidrees, Amjad. "Synthesis and Characterization of Fe (III) Complexes of 8- Hydroxyquinolines and Their Antimicrobial Activity against Staphylococcus aureus and Multidrug-Resistant Staphylococcus aureus ." Doctoral dissertation, Kent State University, 2025. http://rave.ohiolink.edu/etdc/view?acc_num=kent1745607965941392

    Chicago Manual of Style (17th edition)

kent1745607965941392
11
© 2025, all rights reserved.
This open access ETD is published by Kent State University and OhioLINK.
Release 3.2.12