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THE RELATIONSHIP BETWEEN CHA2DS2-VASc STROKE RISK SCORES AND COGNITIVE FUNCTION PRE- AND POST-BARIATRIC SURGERY

Rochette, Amber D
http://rave.ohiolink.edu/etdc/view?acc_num=kent1493123105118343

Abstract Details

2017, MA, Kent State University, College of Arts and Sciences / Department of Psychological Sciences.
Severe obesity is associated with elevated risk for poor neurocognitive outcomes. The mechanisms underlying this association have not yet been fully elucidated, but cerebrovascular pathology resulting from obesity and its associated vascular risk factors has been identified as a likely contributor. The CHA2DS2-VASc is a clinical composite score used to assess risk for vascular events and has been used to estimate severity of cerebrovascular pathology. Past research shows associations between higher scores on the CHA2DS2-VASc and poorer cognitive function in persons with atrial fibrillation and advanced heart failure. However, no study has examined the predictive validity of CHA2DS2-VASc in persons with severe obesity. The current study examined the relationship between the CHA2DS2-VASc and cognitive function before and after bariatric surgery in a sample of individuals with severe obesity. Data from 87 bariatric surgery patients were extracted from a larger parent project. Cognitive function was assessed at baseline and 12 months following bariatric surgery. Self-report questionnaires were completed at the baseline visit to gain medical and demographic information. It was hypothesized that CHA2DS2-VASc scores would predict cognitive function in individuals with severe obesity prior to bariatric surgery, as well as improvements in cognitive function 12 months post-surgery. Additionally, the CHA2DS2-VASc was hypothesized to predict percent weight loss. Analyses revealed significant improvements in cognitive function from pre- to post-surgery in domains of memory, attention, and executive function. No significant associations were observed between the CHA2DS2-VASc and cognitive function at baseline and the stroke risk score did not predict the cognitive improvements seen in memory, executive function, or attention post-surgery. However, an association was found between CHA2DS2-VASc scores and percent weight loss 12 months post-surgery, such that higher CHA2DS2-VASc scores were negatively associated with percent weight loss. Future work is needed to clarify these findings and determine whether the CHA2DS2-VASc may have clinical utility in this population.
John Gunstad (Advisor)
60 p.
Psychology
bariatric surgery; cognitive function; screening; stroke risk score

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Citations

  • Rochette, A. D. (2017). THE RELATIONSHIP BETWEEN CHA2DS2-VASc STROKE RISK SCORES AND COGNITIVE FUNCTION PRE- AND POST-BARIATRIC SURGERY [Master's thesis, Kent State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=kent1493123105118343

    APA Style (7th edition)

  • Rochette, Amber. THE RELATIONSHIP BETWEEN CHA2DS2-VASc STROKE RISK SCORES AND COGNITIVE FUNCTION PRE- AND POST-BARIATRIC SURGERY. 2017. Kent State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=kent1493123105118343.

    MLA Style (8th edition)

  • Rochette, Amber. "THE RELATIONSHIP BETWEEN CHA2DS2-VASc STROKE RISK SCORES AND COGNITIVE FUNCTION PRE- AND POST-BARIATRIC SURGERY." Master's thesis, Kent State University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=kent1493123105118343

    Chicago Manual of Style (17th edition)

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This open access ETD is published by Kent State University and OhioLINK.