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Synthesis, Spectroscopy, Electrochemical, and DNA Photocleavage Studies of Ru(II)-Polypyridyl-BODIPY Complexes

Setter, Darcy Nicole
http://orcid.org/0009-0006-7086-2580
http://rave.ohiolink.edu/etdc/view?acc_num=dayton1714734157904402

Abstract Details

2024, Master of Science (M.S.), University of Dayton, Chemistry.
Two BODIPY dyes with varying substituents have been synthesized and characterized. Coordination of [Ru(bpy)2Cl]+ complexes to different N-atoms, depending on the structure of the dye, resulting in a series of BODPIY-Ru(II) complexes, RuBDP-1 and Ru2BDP-2. The spectroscopic and electrochemical properties of the BODIPY dyes and their Ru(II) analogs have been characterized. The electronic spectra of these compounds reveal the intense absorption typical of the (π-π*) transition localized on the BODIPY core. Additional metal-centered charge transfer transitions associated with the [Ru(bpy)2Cl]+ moieties are observed at higher energy compared to the BODIPY transitions. RuBDP-1 exhibits significant singlet oxygen generation determined using a singlet oxygen trap in acetonitrile solutions. Ru2BDP-2 demonstrates the ability to generate singlet oxygen within the PDT window; however, it is limited in its quantum yield of singlet oxygen which translates to its limited ability to photocleave cpDNA.
Shawn Swavey (Advisor)
Justin Biffinger (Committee Member)
Vladimir Benin (Committee Member)
54 p.
Biochemistry; Chemistry
BODIPY Ruthenium Photodynamic Therapy Reactive Oxygen Species Cancer Treatment

Recommended Citations

Citations

  • Setter, D. N. (2024). Synthesis, Spectroscopy, Electrochemical, and DNA Photocleavage Studies of Ru(II)-Polypyridyl-BODIPY Complexes [Master's thesis, University of Dayton]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=dayton1714734157904402

    APA Style (7th edition)

  • Setter, Darcy. Synthesis, Spectroscopy, Electrochemical, and DNA Photocleavage Studies of Ru(II)-Polypyridyl-BODIPY Complexes. 2024. University of Dayton, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=dayton1714734157904402.

    MLA Style (8th edition)

  • Setter, Darcy. "Synthesis, Spectroscopy, Electrochemical, and DNA Photocleavage Studies of Ru(II)-Polypyridyl-BODIPY Complexes." Master's thesis, University of Dayton, 2024. http://rave.ohiolink.edu/etdc/view?acc_num=dayton1714734157904402

    Chicago Manual of Style (17th edition)

dayton1714734157904402
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© 2024, all rights reserved.
This open access ETD is published by University of Dayton and OhioLINK.