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Dissertation Jeehun Kim.pdf (4.04 MB)

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NOVEL QUANTITATIVE MRI ACQUISITION FOR ACCESSIBLE APPLICATION

Kim, Jeehun
http://orcid.org/0000-0002-5440-4057
http://rave.ohiolink.edu/etdc/view?acc_num=case1723134875636593

Abstract Details

2024, Doctor of Philosophy, Case Western Reserve University, EECS - Electrical Engineering.
Quantitative Magnetic Resonance Imaging (qMRI) is a powerful tool for detecting biochemical abnormalities without harmful ionizing radiation and invasive procedure, which can significantly enhance early disease diagnosis and progression monitoring compared to standard morphological MRI. Osteoarthritis is a disease significantly impacting joint function, mobility, and quality of life, often leading to chronic pain and reduced physical activity. Despite the significant impact, the disease lacks sensitive biomarker that can detect and track the disease progression from an early stage which can help improve patient outcomes and develop effective treatment for the disease. qMRI, due to its sensitivity to biochemical properties, provide multiple candidates that may serve as imaging biomarkers for OA. Among them, T2 and T1ρ have advantage of not requiring special coil nor contrast agent. However, challenges need to be addressed to expand the accessibility of the technique and successful translation to be used in large scale clinical trials and in clinical practice. In this study, novel quantitative T2 and T1ρ acquisition techniques were developed to enhance reliability and enable faster acquisition.
Xiaojuan Li (Advisor)
Mark Griswold (Committee Member)
Xin Yu (Committee Member)
Cenk Cavusoglu (Committee Chair)
106 p.
Biomedical Engineering; Electrical Engineering
Magnetic Resonance Imaging; T2; T1ρ; Reproducibility; Phantom; Accelerated Reconstruction

Recommended Citations

Citations

  • Kim, J. (2024). NOVEL QUANTITATIVE MRI ACQUISITION FOR ACCESSIBLE APPLICATION [Doctoral dissertation, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1723134875636593

    APA Style (7th edition)

  • Kim, Jeehun. NOVEL QUANTITATIVE MRI ACQUISITION FOR ACCESSIBLE APPLICATION. 2024. Case Western Reserve University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=case1723134875636593.

    MLA Style (8th edition)

  • Kim, Jeehun. "NOVEL QUANTITATIVE MRI ACQUISITION FOR ACCESSIBLE APPLICATION." Doctoral dissertation, Case Western Reserve University, 2024. http://rave.ohiolink.edu/etdc/view?acc_num=case1723134875636593

    Chicago Manual of Style (17th edition)

case1723134875636593
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© 2024, all rights reserved.
This open access ETD is published by Case Western Reserve University School of Graduate Studies and OhioLINK.