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Full text release has been delayed at the author's request until August 16, 2026

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Regulation of TLR Signaling in Dendritic Cells by NF-κB c-Rel

Liu, Angela Rose
http://orcid.org/0000-0001-7148-5605
http://rave.ohiolink.edu/etdc/view?acc_num=case1720987322924302

Abstract Details

2024, Doctor of Philosophy, Case Western Reserve University, Pathology.
Activation of Toll-like Receptors (TLRs) induces inflammation regulated by members of the nuclear factor kappaB (NF-κB) transcription factor family. NF-κB c-Rel, a subunit of NF-κB, is a key regulator of inflammatory signaling, and is critical in specific dendritic cell functions. Dendritic cells bridge the innate and adaptive immune response through the secretion of cytokines, sampling and presentation of antigens, and activation of naïve T cells during immune response. In this work, we describe the role of c-Rel following TLR activation as an important regulator of dendritic cell function. We describe the TLR7/c-Rel signaling axis and its critical role in the expression of inflammatory cytokines needed for psoriasis pathogenesis. We found that TLR7 agonism, and not application of its vehicle compound isostearic acid, is the primary driver of the Aldara-induced psoriasis mouse model, thus elucidating important mechanisms behind disease models. Finally, we describe how the increase in O-GlcNAcylation, and the enhancement of c-Rel specific O-GlcNAcylation, during TLR4 signaling regulates dendritic cell activation. Together, this work expands on the fundamental understanding behind how c-Rel acts as a transcriptional regulator during TLR signaling, and the downstream consequences in disease propagation.
Parameswaran Ramakrishnan (Advisor)
George Dubyak (Committee Chair)
Clive Hamlin (Committee Member)
Neetu Gupta (Committee Member)
Alex Huang (Committee Member)
263 p.
Biochemistry; Immunology; Molecular Biology; Pathology
NF-κB; c-Rel; dendritic cell; TLR7; cell signaling; inflammation

Recommended Citations

Citations

  • Liu, A. R. (2024). Regulation of TLR Signaling in Dendritic Cells by NF-κB c-Rel [Doctoral dissertation, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1720987322924302

    APA Style (7th edition)

  • Liu, Angela. Regulation of TLR Signaling in Dendritic Cells by NF-κB c-Rel. 2024. Case Western Reserve University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=case1720987322924302.

    MLA Style (8th edition)

  • Liu, Angela. "Regulation of TLR Signaling in Dendritic Cells by NF-κB c-Rel." Doctoral dissertation, Case Western Reserve University, 2024. http://rave.ohiolink.edu/etdc/view?acc_num=case1720987322924302

    Chicago Manual of Style (17th edition)

case1720987322924302
© 2024, all rights reserved.
This open access ETD is published by Case Western Reserve University School of Graduate Studies and OhioLINK.